A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity. / Stanley, Nathan J; Hutchinson, Mark R; Kvist, Trine; Nielsen, Birgitte; Mathiesen, Jesper M; Bräuner-Osborne, Hans; Avery, Thomas D; Tiekink, Edward R T; Pedersen, Daniel Sejer; Irvine, Rodney J; Abell, Andrew D; Taylor, Dennis K.

I: Bioorganic & Medicinal Chemistry, Bind 18, Nr. 16, 2010, s. 6089-6098.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Stanley, NJ, Hutchinson, MR, Kvist, T, Nielsen, B, Mathiesen, JM, Bräuner-Osborne, H, Avery, TD, Tiekink, ERT, Pedersen, DS, Irvine, RJ, Abell, AD & Taylor, DK 2010, 'A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity', Bioorganic & Medicinal Chemistry, bind 18, nr. 16, s. 6089-6098. https://doi.org/10.1016/j.bmc.2010.06.051

APA

Stanley, N. J., Hutchinson, M. R., Kvist, T., Nielsen, B., Mathiesen, J. M., Bräuner-Osborne, H., Avery, T. D., Tiekink, E. R. T., Pedersen, D. S., Irvine, R. J., Abell, A. D., & Taylor, D. K. (2010). A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity. Bioorganic & Medicinal Chemistry, 18(16), 6089-6098. https://doi.org/10.1016/j.bmc.2010.06.051

Vancouver

Stanley NJ, Hutchinson MR, Kvist T, Nielsen B, Mathiesen JM, Bräuner-Osborne H o.a. A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity. Bioorganic & Medicinal Chemistry. 2010;18(16):6089-6098. https://doi.org/10.1016/j.bmc.2010.06.051

Author

Stanley, Nathan J ; Hutchinson, Mark R ; Kvist, Trine ; Nielsen, Birgitte ; Mathiesen, Jesper M ; Bräuner-Osborne, Hans ; Avery, Thomas D ; Tiekink, Edward R T ; Pedersen, Daniel Sejer ; Irvine, Rodney J ; Abell, Andrew D ; Taylor, Dennis K. / A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity. I: Bioorganic & Medicinal Chemistry. 2010 ; Bind 18, Nr. 16. s. 6089-6098.

Bibtex

@article{cdeac010a6cb11df928f000ea68e967b,
title = "A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity",
abstract = "As part of the vital search towards improved therapeutic agents for the treatment of neuropathic pain, the central nervous system glutamate receptors have become a major focus of research. Outlined herein are the syntheses of two new biologically active 3'-cycloalkyl-substituted carboxycyclopropylglycines, utilizing novel synthetic chemistry. The reaction between substituted 1,2-dioxines and an aminophosphonate furnished the cyclopropane core in a single step with all required stereochemistry of pendant groups. In vitro binding assays at metabotropic glutamate receptors revealed selective activity. In vivo testing in a rodent model of neuropathic pain indicated one amino acid significantly and dose-dependently decreased mechanical allodynia.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Stanley, {Nathan J} and Hutchinson, {Mark R} and Trine Kvist and Birgitte Nielsen and Mathiesen, {Jesper M} and Hans Br{\"a}uner-Osborne and Avery, {Thomas D} and Tiekink, {Edward R T} and Pedersen, {Daniel Sejer} and Irvine, {Rodney J} and Abell, {Andrew D} and Taylor, {Dennis K}",
note = "Keywords: 1,2-Dioxines; Carboxycyclopropylglycines; Metabotropic glutamate receptors; In vivo; Neuropathic pain; Allodynia",
year = "2010",
doi = "10.1016/j.bmc.2010.06.051",
language = "English",
volume = "18",
pages = "6089--6098",
journal = "Bioorganic & Medicinal Chemistry",
issn = "0968-0896",
publisher = "Pergamon Press",
number = "16",

}

RIS

TY - JOUR

T1 - A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity

AU - Stanley, Nathan J

AU - Hutchinson, Mark R

AU - Kvist, Trine

AU - Nielsen, Birgitte

AU - Mathiesen, Jesper M

AU - Bräuner-Osborne, Hans

AU - Avery, Thomas D

AU - Tiekink, Edward R T

AU - Pedersen, Daniel Sejer

AU - Irvine, Rodney J

AU - Abell, Andrew D

AU - Taylor, Dennis K

N1 - Keywords: 1,2-Dioxines; Carboxycyclopropylglycines; Metabotropic glutamate receptors; In vivo; Neuropathic pain; Allodynia

PY - 2010

Y1 - 2010

N2 - As part of the vital search towards improved therapeutic agents for the treatment of neuropathic pain, the central nervous system glutamate receptors have become a major focus of research. Outlined herein are the syntheses of two new biologically active 3'-cycloalkyl-substituted carboxycyclopropylglycines, utilizing novel synthetic chemistry. The reaction between substituted 1,2-dioxines and an aminophosphonate furnished the cyclopropane core in a single step with all required stereochemistry of pendant groups. In vitro binding assays at metabotropic glutamate receptors revealed selective activity. In vivo testing in a rodent model of neuropathic pain indicated one amino acid significantly and dose-dependently decreased mechanical allodynia.

AB - As part of the vital search towards improved therapeutic agents for the treatment of neuropathic pain, the central nervous system glutamate receptors have become a major focus of research. Outlined herein are the syntheses of two new biologically active 3'-cycloalkyl-substituted carboxycyclopropylglycines, utilizing novel synthetic chemistry. The reaction between substituted 1,2-dioxines and an aminophosphonate furnished the cyclopropane core in a single step with all required stereochemistry of pendant groups. In vitro binding assays at metabotropic glutamate receptors revealed selective activity. In vivo testing in a rodent model of neuropathic pain indicated one amino acid significantly and dose-dependently decreased mechanical allodynia.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1016/j.bmc.2010.06.051

DO - 10.1016/j.bmc.2010.06.051

M3 - Journal article

C2 - 20638290

VL - 18

SP - 6089

EP - 6098

JO - Bioorganic & Medicinal Chemistry

JF - Bioorganic & Medicinal Chemistry

SN - 0968-0896

IS - 16

ER -

ID: 21361781