Association of schistosome infection with adiposity in Tanzania

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Association of schistosome infection with adiposity in Tanzania. / Pham, Khanh; PrayGod, George; Faurholt-Jepsen, Daniel; Olsen, Mette Frahm; Kavishe, Bazil; Kitilya, Brenda; Corstjens, Paul L A M; de Dood, Claudia J; Friis, Henrik; Filteau, Suzanne; Downs, Jennifer A; Peck, Robert N.

I: Frontiers in Public Health, Bind 10, 1008101, 2023.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Pham, K, PrayGod, G, Faurholt-Jepsen, D, Olsen, MF, Kavishe, B, Kitilya, B, Corstjens, PLAM, de Dood, CJ, Friis, H, Filteau, S, Downs, JA & Peck, RN 2023, 'Association of schistosome infection with adiposity in Tanzania', Frontiers in Public Health, bind 10, 1008101. https://doi.org/10.3389/fpubh.2022.1008101

APA

Pham, K., PrayGod, G., Faurholt-Jepsen, D., Olsen, M. F., Kavishe, B., Kitilya, B., Corstjens, P. L. A. M., de Dood, C. J., Friis, H., Filteau, S., Downs, J. A., & Peck, R. N. (2023). Association of schistosome infection with adiposity in Tanzania. Frontiers in Public Health, 10, [1008101]. https://doi.org/10.3389/fpubh.2022.1008101

Vancouver

Pham K, PrayGod G, Faurholt-Jepsen D, Olsen MF, Kavishe B, Kitilya B o.a. Association of schistosome infection with adiposity in Tanzania. Frontiers in Public Health. 2023;10. 1008101. https://doi.org/10.3389/fpubh.2022.1008101

Author

Pham, Khanh ; PrayGod, George ; Faurholt-Jepsen, Daniel ; Olsen, Mette Frahm ; Kavishe, Bazil ; Kitilya, Brenda ; Corstjens, Paul L A M ; de Dood, Claudia J ; Friis, Henrik ; Filteau, Suzanne ; Downs, Jennifer A ; Peck, Robert N. / Association of schistosome infection with adiposity in Tanzania. I: Frontiers in Public Health. 2023 ; Bind 10.

Bibtex

@article{d49bf2f2cd2f492a90af90007d88bdba,
title = "Association of schistosome infection with adiposity in Tanzania",
abstract = "Background: Observational studies in humans have reported a link between schistosome infection and lower adiposity, but this may be explained by socioeconomic and demographic factors, intensity of infection, or common co-infections such as HIV.Methods: This was a cross-sectional study that investigated the relationship between schistosome infection and adiposity in a large, well-described cohort of Tanzanian adults living with and without HIV. Cross-sectional data were collected among adults living in Mwanza, Tanzania who were enrolled in the Chronic Infections, Co-morbidities and Diabetes in Africa (CICADA) cohort study. Schistosome circulating anodic antigen, secreted by both Schistosoma mansoni and haematobium which are endemic to Tanzania, was quantified from stored samples. Schistosome infection diagnosed by serum circulating anodic antigen levels. The primary outcome was fat mass measured by bioimpedance analysis. Secondary outcomes included fat-free mass, waist circumference, mid-upper arm circumference, and body mass index.Results: The study enrolled 1,947 adults, of whom 1,923 (98.8%) had serum available for schistosome testing. Of these, 873 (45.4%) had a serum circulating anodic antigen ≥30 pg/mL, indicating schistosome infection. Compared to uninfected individuals, those with schistosome infections had -1.1 kg [95% CI -1.9 to -0.3] lower fat mass after adjusting for age, sex, physical activity, tobacco use, education level, and socioeconomic status. Infected participants also had lower waist circumference, mid-upper arm circumference, and body mass index. Fat-free mass was not different between the two groups. Neither being HIV-infected, nor receiving antiretroviral therapy, modified associations between schistosome infection and adiposity. These associations were also not affected by Schistosoma worm burden.Conclusions: Schistosome infection was associated with lower fat mass and less central adiposity without a difference in muscle mass, irrespective of confounders, HIV status, or the intensity of schistosome infection. Future studies should adjust for socioeconomic and demographic factors that are associated with schistosome infection and adiposity. Identifying mechanistic pathways by which schistosome infection reduces adiposity while preserving muscle mass could yield new strategies for obesity control and cardiovascular disease prevention.",
keywords = "Faculty of Science, Schistosome infection, Adiposity, HIV, Antiretroviral therapy, Cardiovascular disease",
author = "Khanh Pham and George PrayGod and Daniel Faurholt-Jepsen and Olsen, {Mette Frahm} and Bazil Kavishe and Brenda Kitilya and Corstjens, {Paul L A M} and {de Dood}, {Claudia J} and Henrik Friis and Suzanne Filteau and Downs, {Jennifer A} and Peck, {Robert N}",
note = "Copyright {\textcopyright} 2023 Pham, PrayGod, Faurholt-Jepsen, Olsen, Kavishe, Kitilya, Corstjens, de Dood, Friis, Filteau, Downs and Peck.",
year = "2023",
doi = "10.3389/fpubh.2022.1008101",
language = "English",
volume = "10",
journal = "Frontiers in Public Health",
issn = "2296-2565",
publisher = "Frontiers Media",

}

RIS

TY - JOUR

T1 - Association of schistosome infection with adiposity in Tanzania

AU - Pham, Khanh

AU - PrayGod, George

AU - Faurholt-Jepsen, Daniel

AU - Olsen, Mette Frahm

AU - Kavishe, Bazil

AU - Kitilya, Brenda

AU - Corstjens, Paul L A M

AU - de Dood, Claudia J

AU - Friis, Henrik

AU - Filteau, Suzanne

AU - Downs, Jennifer A

AU - Peck, Robert N

N1 - Copyright © 2023 Pham, PrayGod, Faurholt-Jepsen, Olsen, Kavishe, Kitilya, Corstjens, de Dood, Friis, Filteau, Downs and Peck.

PY - 2023

Y1 - 2023

N2 - Background: Observational studies in humans have reported a link between schistosome infection and lower adiposity, but this may be explained by socioeconomic and demographic factors, intensity of infection, or common co-infections such as HIV.Methods: This was a cross-sectional study that investigated the relationship between schistosome infection and adiposity in a large, well-described cohort of Tanzanian adults living with and without HIV. Cross-sectional data were collected among adults living in Mwanza, Tanzania who were enrolled in the Chronic Infections, Co-morbidities and Diabetes in Africa (CICADA) cohort study. Schistosome circulating anodic antigen, secreted by both Schistosoma mansoni and haematobium which are endemic to Tanzania, was quantified from stored samples. Schistosome infection diagnosed by serum circulating anodic antigen levels. The primary outcome was fat mass measured by bioimpedance analysis. Secondary outcomes included fat-free mass, waist circumference, mid-upper arm circumference, and body mass index.Results: The study enrolled 1,947 adults, of whom 1,923 (98.8%) had serum available for schistosome testing. Of these, 873 (45.4%) had a serum circulating anodic antigen ≥30 pg/mL, indicating schistosome infection. Compared to uninfected individuals, those with schistosome infections had -1.1 kg [95% CI -1.9 to -0.3] lower fat mass after adjusting for age, sex, physical activity, tobacco use, education level, and socioeconomic status. Infected participants also had lower waist circumference, mid-upper arm circumference, and body mass index. Fat-free mass was not different between the two groups. Neither being HIV-infected, nor receiving antiretroviral therapy, modified associations between schistosome infection and adiposity. These associations were also not affected by Schistosoma worm burden.Conclusions: Schistosome infection was associated with lower fat mass and less central adiposity without a difference in muscle mass, irrespective of confounders, HIV status, or the intensity of schistosome infection. Future studies should adjust for socioeconomic and demographic factors that are associated with schistosome infection and adiposity. Identifying mechanistic pathways by which schistosome infection reduces adiposity while preserving muscle mass could yield new strategies for obesity control and cardiovascular disease prevention.

AB - Background: Observational studies in humans have reported a link between schistosome infection and lower adiposity, but this may be explained by socioeconomic and demographic factors, intensity of infection, or common co-infections such as HIV.Methods: This was a cross-sectional study that investigated the relationship between schistosome infection and adiposity in a large, well-described cohort of Tanzanian adults living with and without HIV. Cross-sectional data were collected among adults living in Mwanza, Tanzania who were enrolled in the Chronic Infections, Co-morbidities and Diabetes in Africa (CICADA) cohort study. Schistosome circulating anodic antigen, secreted by both Schistosoma mansoni and haematobium which are endemic to Tanzania, was quantified from stored samples. Schistosome infection diagnosed by serum circulating anodic antigen levels. The primary outcome was fat mass measured by bioimpedance analysis. Secondary outcomes included fat-free mass, waist circumference, mid-upper arm circumference, and body mass index.Results: The study enrolled 1,947 adults, of whom 1,923 (98.8%) had serum available for schistosome testing. Of these, 873 (45.4%) had a serum circulating anodic antigen ≥30 pg/mL, indicating schistosome infection. Compared to uninfected individuals, those with schistosome infections had -1.1 kg [95% CI -1.9 to -0.3] lower fat mass after adjusting for age, sex, physical activity, tobacco use, education level, and socioeconomic status. Infected participants also had lower waist circumference, mid-upper arm circumference, and body mass index. Fat-free mass was not different between the two groups. Neither being HIV-infected, nor receiving antiretroviral therapy, modified associations between schistosome infection and adiposity. These associations were also not affected by Schistosoma worm burden.Conclusions: Schistosome infection was associated with lower fat mass and less central adiposity without a difference in muscle mass, irrespective of confounders, HIV status, or the intensity of schistosome infection. Future studies should adjust for socioeconomic and demographic factors that are associated with schistosome infection and adiposity. Identifying mechanistic pathways by which schistosome infection reduces adiposity while preserving muscle mass could yield new strategies for obesity control and cardiovascular disease prevention.

KW - Faculty of Science

KW - Schistosome infection

KW - Adiposity

KW - HIV

KW - Antiretroviral therapy

KW - Cardiovascular disease

U2 - 10.3389/fpubh.2022.1008101

DO - 10.3389/fpubh.2022.1008101

M3 - Journal article

C2 - 36684996

VL - 10

JO - Frontiers in Public Health

JF - Frontiers in Public Health

SN - 2296-2565

M1 - 1008101

ER -

ID: 333469894