Characterisation of enterocolitis in the piroxicam-accelerated interleukin-10 knock out mouse: a model mimicking inflammatory bowel disease

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Standard

Characterisation of enterocolitis in the piroxicam-accelerated interleukin-10 knock out mouse : a model mimicking inflammatory bowel disease. / Holgersen, Kristine; Kvist, Peter Helding ; Markholst, Helle; Hansen, Axel Jacob Kornerup; Holm, Thomas Lindebo.

I: Journal of Crohn's and Colitis, Bind 8, Nr. 2, 2014, s. 147-160.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Holgersen, K, Kvist, PH, Markholst, H, Hansen, AJK & Holm, TL 2014, 'Characterisation of enterocolitis in the piroxicam-accelerated interleukin-10 knock out mouse: a model mimicking inflammatory bowel disease', Journal of Crohn's and Colitis, bind 8, nr. 2, s. 147-160. https://doi.org/10.1016/j.crohns.2013.08.002

APA

Holgersen, K., Kvist, P. H., Markholst, H., Hansen, A. J. K., & Holm, T. L. (2014). Characterisation of enterocolitis in the piroxicam-accelerated interleukin-10 knock out mouse: a model mimicking inflammatory bowel disease. Journal of Crohn's and Colitis, 8(2), 147-160. https://doi.org/10.1016/j.crohns.2013.08.002

Vancouver

Holgersen K, Kvist PH, Markholst H, Hansen AJK, Holm TL. Characterisation of enterocolitis in the piroxicam-accelerated interleukin-10 knock out mouse: a model mimicking inflammatory bowel disease. Journal of Crohn's and Colitis. 2014;8(2):147-160. https://doi.org/10.1016/j.crohns.2013.08.002

Author

Holgersen, Kristine ; Kvist, Peter Helding ; Markholst, Helle ; Hansen, Axel Jacob Kornerup ; Holm, Thomas Lindebo. / Characterisation of enterocolitis in the piroxicam-accelerated interleukin-10 knock out mouse : a model mimicking inflammatory bowel disease. I: Journal of Crohn's and Colitis. 2014 ; Bind 8, Nr. 2. s. 147-160.

Bibtex

@article{9cfce6c5a78f4d0ab6b1c34cf60020b0,
title = "Characterisation of enterocolitis in the piroxicam-accelerated interleukin-10 knock out mouse: a model mimicking inflammatory bowel disease",
abstract = "Background: In inflammatory bowel disease a defective mucosal barrier, a dysregulated immune response and an excessive reactivity against the gut microbiota are assumed to cause a breakdown of the intestinal homeostasis and lead to chronic inflammation. Piroxicam treatment is a method for induction of colitis in IL-10 k.o. mice, which integrates a dysfunction of both the intestinal barrier and the immune system. However, the translational value of this model has not been thoroughly clarified. Aim: To characterise the piroxicam-accelerated colitis (PAC) IL-10 k.o. model with respect to clinical features, pathogenic mechanisms and its ability to respond to existing therapies. Methods: The PAC IL-10 k.o. model was established on a C57BL/6 J background and the clinical manifestations, immunological mechanisms and efficacy of ampicillin and anti-IL-12/23p40 treatment were assessed.",
keywords = "Faculty of Health and Medical Sciences, Inflammatory bowel disease, Crohn's disease, Interleukin-10 knock out mouse, Piroxicam",
author = "Kristine Holgersen and Kvist, {Peter Helding} and Helle Markholst and Hansen, {Axel Jacob Kornerup} and Holm, {Thomas Lindebo}",
year = "2014",
doi = "10.1016/j.crohns.2013.08.002",
language = "English",
volume = "8",
pages = "147--160",
journal = "Journal of Crohn's and Colitis",
issn = "1873-9946",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Characterisation of enterocolitis in the piroxicam-accelerated interleukin-10 knock out mouse

T2 - a model mimicking inflammatory bowel disease

AU - Holgersen, Kristine

AU - Kvist, Peter Helding

AU - Markholst, Helle

AU - Hansen, Axel Jacob Kornerup

AU - Holm, Thomas Lindebo

PY - 2014

Y1 - 2014

N2 - Background: In inflammatory bowel disease a defective mucosal barrier, a dysregulated immune response and an excessive reactivity against the gut microbiota are assumed to cause a breakdown of the intestinal homeostasis and lead to chronic inflammation. Piroxicam treatment is a method for induction of colitis in IL-10 k.o. mice, which integrates a dysfunction of both the intestinal barrier and the immune system. However, the translational value of this model has not been thoroughly clarified. Aim: To characterise the piroxicam-accelerated colitis (PAC) IL-10 k.o. model with respect to clinical features, pathogenic mechanisms and its ability to respond to existing therapies. Methods: The PAC IL-10 k.o. model was established on a C57BL/6 J background and the clinical manifestations, immunological mechanisms and efficacy of ampicillin and anti-IL-12/23p40 treatment were assessed.

AB - Background: In inflammatory bowel disease a defective mucosal barrier, a dysregulated immune response and an excessive reactivity against the gut microbiota are assumed to cause a breakdown of the intestinal homeostasis and lead to chronic inflammation. Piroxicam treatment is a method for induction of colitis in IL-10 k.o. mice, which integrates a dysfunction of both the intestinal barrier and the immune system. However, the translational value of this model has not been thoroughly clarified. Aim: To characterise the piroxicam-accelerated colitis (PAC) IL-10 k.o. model with respect to clinical features, pathogenic mechanisms and its ability to respond to existing therapies. Methods: The PAC IL-10 k.o. model was established on a C57BL/6 J background and the clinical manifestations, immunological mechanisms and efficacy of ampicillin and anti-IL-12/23p40 treatment were assessed.

KW - Faculty of Health and Medical Sciences

KW - Inflammatory bowel disease

KW - Crohn's disease

KW - Interleukin-10 knock out mouse

KW - Piroxicam

U2 - 10.1016/j.crohns.2013.08.002

DO - 10.1016/j.crohns.2013.08.002

M3 - Journal article

C2 - 23994255

VL - 8

SP - 147

EP - 160

JO - Journal of Crohn's and Colitis

JF - Journal of Crohn's and Colitis

SN - 1873-9946

IS - 2

ER -

ID: 68162694