Early life DNA vaccination with the H gene of Canine distemper virus induces robust protection against distemper

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Standard

Early life DNA vaccination with the H gene of Canine distemper virus induces robust protection against distemper. / Jensen, Trine Hammer; Nielsen, Line; Aasted, Bent; Blixenkrone-Møller, Merete.

I: Vaccine, Bind 27, Nr. 38, 2009, s. 5178–5183.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Jensen, TH, Nielsen, L, Aasted, B & Blixenkrone-Møller, M 2009, 'Early life DNA vaccination with the H gene of Canine distemper virus induces robust protection against distemper', Vaccine, bind 27, nr. 38, s. 5178–5183. https://doi.org/10.1016/j.vaccine.2009.06.077

APA

Jensen, T. H., Nielsen, L., Aasted, B., & Blixenkrone-Møller, M. (2009). Early life DNA vaccination with the H gene of Canine distemper virus induces robust protection against distemper. Vaccine, 27(38), 5178–5183. https://doi.org/10.1016/j.vaccine.2009.06.077

Vancouver

Jensen TH, Nielsen L, Aasted B, Blixenkrone-Møller M. Early life DNA vaccination with the H gene of Canine distemper virus induces robust protection against distemper. Vaccine. 2009;27(38):5178–5183. https://doi.org/10.1016/j.vaccine.2009.06.077

Author

Jensen, Trine Hammer ; Nielsen, Line ; Aasted, Bent ; Blixenkrone-Møller, Merete. / Early life DNA vaccination with the H gene of Canine distemper virus induces robust protection against distemper. I: Vaccine. 2009 ; Bind 27, Nr. 38. s. 5178–5183.

Bibtex

@article{4ac362707da811de8bc9000ea68e967b,
title = "Early life DNA vaccination with the H gene of Canine distemper virus induces robust protection against distemper",
abstract = "Young mink kits (n = 8)were vaccinated withDNA plasmids encoding the viral haemagglutinin protein (H) of a vaccine strain of Canine distemper virus (CDV). Virus neutralising (VN) antibodieswere induced after 2 immunisations and after the third immunisation all kits had high VN antibody titres. The VN antibody titres remained high for more than 4 months and the mink were protected against viraemia, lymphopenia, clinical disease and changes in the percentage of IFN- producing peripheral blood leucocytes after challenge inoculation with a recent wild type strain of CDV. Essentially, these results demonstrate that early life DNA vaccination with the H gene of a CDV vaccine strain induced robust protective immunity against a recent wild type CDV.",
keywords = "Former Faculty of Life Sciences",
author = "Jensen, {Trine Hammer} and Line Nielsen and Bent Aasted and Merete Blixenkrone-M{\o}ller",
year = "2009",
doi = "10.1016/j.vaccine.2009.06.077",
language = "English",
volume = "27",
pages = "5178–5183",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier",
number = "38",

}

RIS

TY - JOUR

T1 - Early life DNA vaccination with the H gene of Canine distemper virus induces robust protection against distemper

AU - Jensen, Trine Hammer

AU - Nielsen, Line

AU - Aasted, Bent

AU - Blixenkrone-Møller, Merete

PY - 2009

Y1 - 2009

N2 - Young mink kits (n = 8)were vaccinated withDNA plasmids encoding the viral haemagglutinin protein (H) of a vaccine strain of Canine distemper virus (CDV). Virus neutralising (VN) antibodieswere induced after 2 immunisations and after the third immunisation all kits had high VN antibody titres. The VN antibody titres remained high for more than 4 months and the mink were protected against viraemia, lymphopenia, clinical disease and changes in the percentage of IFN- producing peripheral blood leucocytes after challenge inoculation with a recent wild type strain of CDV. Essentially, these results demonstrate that early life DNA vaccination with the H gene of a CDV vaccine strain induced robust protective immunity against a recent wild type CDV.

AB - Young mink kits (n = 8)were vaccinated withDNA plasmids encoding the viral haemagglutinin protein (H) of a vaccine strain of Canine distemper virus (CDV). Virus neutralising (VN) antibodieswere induced after 2 immunisations and after the third immunisation all kits had high VN antibody titres. The VN antibody titres remained high for more than 4 months and the mink were protected against viraemia, lymphopenia, clinical disease and changes in the percentage of IFN- producing peripheral blood leucocytes after challenge inoculation with a recent wild type strain of CDV. Essentially, these results demonstrate that early life DNA vaccination with the H gene of a CDV vaccine strain induced robust protective immunity against a recent wild type CDV.

KW - Former Faculty of Life Sciences

U2 - 10.1016/j.vaccine.2009.06.077

DO - 10.1016/j.vaccine.2009.06.077

M3 - Journal article

C2 - 19596418

VL - 27

SP - 5178

EP - 5183

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 38

ER -

ID: 13458253