Evolution of the diagnostic value of "the sugar of the blood": hitting the sweet spot to identify alterations in glucose dynamics
Publikation: Bidrag til tidsskrift › Review › fagfællebedømt
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Evolution of the diagnostic value of "the sugar of the blood": hitting the sweet spot to identify alterations in glucose dynamics. / Magkos, Faidon; Reeds, Dominic N; Mittendorfer, Bettina.
I: Physiological Reviews, Bind 103, Nr. 1, 2023, s. 7-30.Publikation: Bidrag til tidsskrift › Review › fagfællebedømt
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TY - JOUR
T1 - Evolution of the diagnostic value of "the sugar of the blood": hitting the sweet spot to identify alterations in glucose dynamics
AU - Magkos, Faidon
AU - Reeds, Dominic N
AU - Mittendorfer, Bettina
N1 - CURIS 2023 NEXS 002
PY - 2023
Y1 - 2023
N2 - In this paper, we provide an overview of the evolution of the definition of hyperglycemia during the past century and the alterations in glucose dynamics that cause fasting and postprandial hyperglycemia. We discuss how extensive mechanistic, physiological research into the factors and pathways that regulate the appearance of glucose in the circulation and its uptake and metabolism by tissues and organs has contributed knowledge that has advanced our understanding of different types of hyperglycemia, namely prediabetes and diabetes and their subtypes (impaired fasting plasma glucose, impaired glucose tolerance, combined impaired fasting plasma glucose, impaired glucose tolerance, type 1 diabetes, type 2 diabetes, gestational diabetes mellitus), their relationships with medical complications, and how to prevent and treat hyperglycemia.
AB - In this paper, we provide an overview of the evolution of the definition of hyperglycemia during the past century and the alterations in glucose dynamics that cause fasting and postprandial hyperglycemia. We discuss how extensive mechanistic, physiological research into the factors and pathways that regulate the appearance of glucose in the circulation and its uptake and metabolism by tissues and organs has contributed knowledge that has advanced our understanding of different types of hyperglycemia, namely prediabetes and diabetes and their subtypes (impaired fasting plasma glucose, impaired glucose tolerance, combined impaired fasting plasma glucose, impaired glucose tolerance, type 1 diabetes, type 2 diabetes, gestational diabetes mellitus), their relationships with medical complications, and how to prevent and treat hyperglycemia.
KW - Faculty of Science
KW - Glucose
KW - Prediabetes
KW - Diabetes
KW - Hyperglycemia
KW - β-cell
KW - Obesity
U2 - 10.1152/physrev.00015.2022
DO - 10.1152/physrev.00015.2022
M3 - Review
C2 - 35635320
VL - 103
SP - 7
EP - 30
JO - Physiological Reviews
JF - Physiological Reviews
SN - 0031-9333
IS - 1
ER -
ID: 308368083