Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Anna Katrina Jógvansdóttir Gradel, Trine Porsgaard, Jens Lykkesfeldt, Torben Seested, Sanne Gram-Nielsen, Niels Rode Kristensen, Hanne Refsgaard

Variability in the effect of subcutaneously administered insulin represents a major challenge in insulin therapy where precise dosing
is required in order to achieve targeted glucose levels. Since this variability is largely influenced by the absorption of insulin, a deeper
understanding of the factors affecting the absorption of insulin from the subcutaneous tissue is necessary in order to improve
glycaemic control and the long-term prognosis in people with diabetes. These factors can be related to either the insulin
preparation, the injection site/patient, or the injection technique. This review highlights the factors affecting insulin absorption
with special attention on the physiological factors at the injection site. In addition, it also provides a detailed description of the
insulin absorption process and the various modifications to this process that have been utilized by the different insulin
preparations available.
OriginalsprogEngelsk
Artikelnummer1205121
TidsskriftJournal of Diabetes Research
Vol/bind2018
Antal sider17
ISSN2314-6745
DOI
StatusUdgivet - 2018

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