Genetic control of disease in an experimental model for Sjögren's syndrome

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Åsa Inga Maria Andersson
Sjögren's syndrome is an autoimmune disease with a complex etiology depending on hereditary and environmental factors. The disease is characterized by lymphocytic infiltration and inflammation in the salivary and lacrimal glands, leading to oral and ocular dryness. To understand the genetic susceptibility in Sjögren's syndrome, studies of disease phenotypes have been performed in the non-obese diabetic (NOD) mouse. By the identification of genetic regions controlling development of autoimmune exocrinopathy in the NOD mouse and by reducing one of these regions considerably, Nguyen et al. in a recent issue of Arthritis Research and Therapy propose candidate genes for development of Sjögren's syndrome.
OriginalsprogEngelsk
TidsskriftArthritis Research & Therapy
Vol/bind11
Udgave nummer1
Sider (fra-til)102
ISSN1478-6362
DOI
StatusUdgivet - 2009

ID: 16862563