Iminolactones from Schizophyllum commune

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Xuemei Liu, Karla Andrea Frydenvang, Huizhen Liu, Lin Zhai, Ming Chen, Carl Erik Olsen, Søren Brøgger Christensen

Schizine A (1) and B (2) the first naturally occurring iminolactones (3,6-dihydro-2H-1,4-oxazin-2-one derivatives) to be reported have been isolated from the fruiting bodies of Schizophyllym commune. In principle the 2-oxazinone moiety might have been formed by a reaction between the amino acids phenylalanine or tryptophan and an α-hydroxyketomniopetal. The alkaloids are unusual in that the carboxyl group of the amino acid precursor is preserved during the biosynthesis. The compounds showed some inhibition of the growth of cancer cells.
OriginalsprogEngelsk
TidsskriftJournal of Natural Products
Vol/bind78
Udgave nummer5
Sider (fra-til)1165-1168
Antal sider4
ISSN0974-5211
DOI
StatusUdgivet - 2015

ID: 137476779