Influence of lipid composition and drug load on the in vitro performance of self-nanoemulsifying drug delivery systems

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Standard

Influence of lipid composition and drug load on the in vitro performance of self-nanoemulsifying drug delivery systems. / Thomas, Nicky; Müllertz, Anette; Graf, Anja; Rades, Thomas.

I: Journal of Pharmaceutical Sciences, Bind 101, Nr. 5, 2012, s. 1721-1731.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Thomas, N, Müllertz, A, Graf, A & Rades, T 2012, 'Influence of lipid composition and drug load on the in vitro performance of self-nanoemulsifying drug delivery systems', Journal of Pharmaceutical Sciences, bind 101, nr. 5, s. 1721-1731. https://doi.org/10.1002/jps.23054.

APA

Thomas, N., Müllertz, A., Graf, A., & Rades, T. (2012). Influence of lipid composition and drug load on the in vitro performance of self-nanoemulsifying drug delivery systems. Journal of Pharmaceutical Sciences, 101(5), 1721-1731. https://doi.org/10.1002/jps.23054.

Vancouver

Thomas N, Müllertz A, Graf A, Rades T. Influence of lipid composition and drug load on the in vitro performance of self-nanoemulsifying drug delivery systems. Journal of Pharmaceutical Sciences. 2012;101(5):1721-1731. https://doi.org/10.1002/jps.23054.

Author

Thomas, Nicky ; Müllertz, Anette ; Graf, Anja ; Rades, Thomas. / Influence of lipid composition and drug load on the in vitro performance of self-nanoemulsifying drug delivery systems. I: Journal of Pharmaceutical Sciences. 2012 ; Bind 101, Nr. 5. s. 1721-1731.

Bibtex

@article{c2b6858755554a5785589d5f42fb6032,
title = "Influence of lipid composition and drug load on the in vitro performance of self-nanoemulsifying drug delivery systems",
abstract = "The influence of lipid composition and drug load on the in vitro performance of lipid-based drug delivery systems was investigated during dispersion and in vitro lipolysis of two self-nanoemulsifying drug delivery systems (SNEDDS). SNEDDS preconcentrates consisted of the same mass ratios of lipid, surfactant, and cosolvent but varied in the chain length of the lipid component. Utilization of the surfactant Cremophor EL resulted in pronounced changes in the droplet size of dispersed SNEDDS containing increasing drug loads of the poorly water-soluble compound simvastatin (SIM). In contrast, the droplet size of dispersed medium-chain (MC)-SNEDDS based on the surfactant Cremophor RH40 was not affected by increasing drug loads of SIM, whereas the droplet size of the corresponding long-chain (LC)-SNEDDS increased. During 60 min in vitro lipolysis, MC-SNEDDS maintained approximately 95{\%} of SIM in solution, independent of the drug load. At the start of lipolysis of LC-SNEDDS, up to 34{\%} of the drug precipitated. However, the initial precipitate dissolved in the lipolysis medium 30 min after start of in vitro lipolysis. The study suggests that drug load and lipid composition should be considered for the design of SNEDDS. {\circledC} 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:1721–1731, 2012",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Nicky Thomas and Anette M{\"u}llertz and Anja Graf and Thomas Rades",
year = "2012",
doi = "10.1002/jps.23054.",
language = "English",
volume = "101",
pages = "1721--1731",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Influence of lipid composition and drug load on the in vitro performance of self-nanoemulsifying drug delivery systems

AU - Thomas, Nicky

AU - Müllertz, Anette

AU - Graf, Anja

AU - Rades, Thomas

PY - 2012

Y1 - 2012

N2 - The influence of lipid composition and drug load on the in vitro performance of lipid-based drug delivery systems was investigated during dispersion and in vitro lipolysis of two self-nanoemulsifying drug delivery systems (SNEDDS). SNEDDS preconcentrates consisted of the same mass ratios of lipid, surfactant, and cosolvent but varied in the chain length of the lipid component. Utilization of the surfactant Cremophor EL resulted in pronounced changes in the droplet size of dispersed SNEDDS containing increasing drug loads of the poorly water-soluble compound simvastatin (SIM). In contrast, the droplet size of dispersed medium-chain (MC)-SNEDDS based on the surfactant Cremophor RH40 was not affected by increasing drug loads of SIM, whereas the droplet size of the corresponding long-chain (LC)-SNEDDS increased. During 60 min in vitro lipolysis, MC-SNEDDS maintained approximately 95% of SIM in solution, independent of the drug load. At the start of lipolysis of LC-SNEDDS, up to 34% of the drug precipitated. However, the initial precipitate dissolved in the lipolysis medium 30 min after start of in vitro lipolysis. The study suggests that drug load and lipid composition should be considered for the design of SNEDDS. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:1721–1731, 2012

AB - The influence of lipid composition and drug load on the in vitro performance of lipid-based drug delivery systems was investigated during dispersion and in vitro lipolysis of two self-nanoemulsifying drug delivery systems (SNEDDS). SNEDDS preconcentrates consisted of the same mass ratios of lipid, surfactant, and cosolvent but varied in the chain length of the lipid component. Utilization of the surfactant Cremophor EL resulted in pronounced changes in the droplet size of dispersed SNEDDS containing increasing drug loads of the poorly water-soluble compound simvastatin (SIM). In contrast, the droplet size of dispersed medium-chain (MC)-SNEDDS based on the surfactant Cremophor RH40 was not affected by increasing drug loads of SIM, whereas the droplet size of the corresponding long-chain (LC)-SNEDDS increased. During 60 min in vitro lipolysis, MC-SNEDDS maintained approximately 95% of SIM in solution, independent of the drug load. At the start of lipolysis of LC-SNEDDS, up to 34% of the drug precipitated. However, the initial precipitate dissolved in the lipolysis medium 30 min after start of in vitro lipolysis. The study suggests that drug load and lipid composition should be considered for the design of SNEDDS. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:1721–1731, 2012

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1002/jps.23054.

DO - 10.1002/jps.23054.

M3 - Journal article

VL - 101

SP - 1721

EP - 1731

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 5

ER -

ID: 40166727