Keratinocyte Carcinoma and Photoprevention: The Protective Actions of Repurposed Pharmaceuticals, Phytochemicals and Vitamins

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Standard

Keratinocyte Carcinoma and Photoprevention : The Protective Actions of Repurposed Pharmaceuticals, Phytochemicals and Vitamins. / Pihl, Celina; Togsverd-Bo, Katrine; Andersen, Flemming; Haedersdal, Merete; Bjerring, Peter; Lerche, Catharina Margrethe.

I: Cancers, Bind 13, Nr. 15, 3684, 2021.

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Harvard

Pihl, C, Togsverd-Bo, K, Andersen, F, Haedersdal, M, Bjerring, P & Lerche, CM 2021, 'Keratinocyte Carcinoma and Photoprevention: The Protective Actions of Repurposed Pharmaceuticals, Phytochemicals and Vitamins', Cancers, bind 13, nr. 15, 3684. https://doi.org/10.3390/cancers13153684

APA

Pihl, C., Togsverd-Bo, K., Andersen, F., Haedersdal, M., Bjerring, P., & Lerche, C. M. (2021). Keratinocyte Carcinoma and Photoprevention: The Protective Actions of Repurposed Pharmaceuticals, Phytochemicals and Vitamins. Cancers, 13(15), [3684]. https://doi.org/10.3390/cancers13153684

Vancouver

Pihl C, Togsverd-Bo K, Andersen F, Haedersdal M, Bjerring P, Lerche CM. Keratinocyte Carcinoma and Photoprevention: The Protective Actions of Repurposed Pharmaceuticals, Phytochemicals and Vitamins. Cancers. 2021;13(15). 3684. https://doi.org/10.3390/cancers13153684

Author

Pihl, Celina ; Togsverd-Bo, Katrine ; Andersen, Flemming ; Haedersdal, Merete ; Bjerring, Peter ; Lerche, Catharina Margrethe. / Keratinocyte Carcinoma and Photoprevention : The Protective Actions of Repurposed Pharmaceuticals, Phytochemicals and Vitamins. I: Cancers. 2021 ; Bind 13, Nr. 15.

Bibtex

@article{2572b3a95f5941a7905d6bede9d132ae,
title = "Keratinocyte Carcinoma and Photoprevention: The Protective Actions of Repurposed Pharmaceuticals, Phytochemicals and Vitamins",
abstract = "Ultraviolet radiation (UVR) arising from sun exposure represents a major risk factor in the development of keratinocyte carcinomas (KCs). UVR exposure induces dysregulated signal transduction, oxidative stress, inflammation, immunosuppression and DNA damage, all of which promote the induction and development of photocarcinogenesis. Because the incidence of KCs is increasing, better prevention strategies are necessary. In the concept of photoprevention, protective compounds are administered either topically or systemically to prevent the effects of UVR and the development of skin cancer. In this review, we provide descriptions of the pathways underlying photocarcinogenesis and an overview of selected photoprotective compounds, such as repurposed pharmaceuticals, plant-derived phytochemicals and vitamins. We discuss the protective potential of these compounds and their effects in pre-clinical and human trials, summarising the mechanisms of action involved in preventing photocarcinogenesis.",
keywords = "Faculty of Health and Medical Sciences, Photoprotection, keratinocyte carcinoma, UV radiation",
author = "Celina Pihl and Katrine Togsverd-Bo and Flemming Andersen and Merete Haedersdal and Peter Bjerring and Lerche, {Catharina Margrethe}",
year = "2021",
doi = "10.3390/cancers13153684",
language = "English",
volume = "13",
journal = "Cancers",
issn = "2072-6694",
publisher = "M D P I AG",
number = "15",

}

RIS

TY - JOUR

T1 - Keratinocyte Carcinoma and Photoprevention

T2 - The Protective Actions of Repurposed Pharmaceuticals, Phytochemicals and Vitamins

AU - Pihl, Celina

AU - Togsverd-Bo, Katrine

AU - Andersen, Flemming

AU - Haedersdal, Merete

AU - Bjerring, Peter

AU - Lerche, Catharina Margrethe

PY - 2021

Y1 - 2021

N2 - Ultraviolet radiation (UVR) arising from sun exposure represents a major risk factor in the development of keratinocyte carcinomas (KCs). UVR exposure induces dysregulated signal transduction, oxidative stress, inflammation, immunosuppression and DNA damage, all of which promote the induction and development of photocarcinogenesis. Because the incidence of KCs is increasing, better prevention strategies are necessary. In the concept of photoprevention, protective compounds are administered either topically or systemically to prevent the effects of UVR and the development of skin cancer. In this review, we provide descriptions of the pathways underlying photocarcinogenesis and an overview of selected photoprotective compounds, such as repurposed pharmaceuticals, plant-derived phytochemicals and vitamins. We discuss the protective potential of these compounds and their effects in pre-clinical and human trials, summarising the mechanisms of action involved in preventing photocarcinogenesis.

AB - Ultraviolet radiation (UVR) arising from sun exposure represents a major risk factor in the development of keratinocyte carcinomas (KCs). UVR exposure induces dysregulated signal transduction, oxidative stress, inflammation, immunosuppression and DNA damage, all of which promote the induction and development of photocarcinogenesis. Because the incidence of KCs is increasing, better prevention strategies are necessary. In the concept of photoprevention, protective compounds are administered either topically or systemically to prevent the effects of UVR and the development of skin cancer. In this review, we provide descriptions of the pathways underlying photocarcinogenesis and an overview of selected photoprotective compounds, such as repurposed pharmaceuticals, plant-derived phytochemicals and vitamins. We discuss the protective potential of these compounds and their effects in pre-clinical and human trials, summarising the mechanisms of action involved in preventing photocarcinogenesis.

KW - Faculty of Health and Medical Sciences

KW - Photoprotection

KW - keratinocyte carcinoma

KW - UV radiation

U2 - 10.3390/cancers13153684

DO - 10.3390/cancers13153684

M3 - Review

VL - 13

JO - Cancers

JF - Cancers

SN - 2072-6694

IS - 15

M1 - 3684

ER -

ID: 274867309