Lymphotropism and host responses during acute wild-type canine distemper virus infections in a highly susceptible natural host

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  • Line Nielsen
  • Mette Søgaard
  • Trine Hammer Jensen
  • Mads Klindt Andersen
  • Aasted, Bent
  • Merete Blixenkrone-Møller
The mechanisms behind the in vivo virulence of immunosuppressive wild-type Morbillivirus infections are still not fully understood. To investigate lymphotropism and host responses we have selected the natural host model of canine distemper virus (CDV) infection in mink. This model displays multisystemic infection similar to measles virus (MV) and rinderpest virus (RPV) infections in their susceptible natural hosts. The wild-type CDVs investigated provoked marked virulence differences inducing mild versus marked to severe acute disease. The mildly virulent wild-type induced transient lymphopenia despite the development of massive infection of peripheral blood mononuclear cells (PBMCs) exceeding that determined for the highly virulent wild-type, indicating an inverse relationship between acute virulence and the extent of viremia between the investigated wild-types. Single-cell cytokine production in PBMCs was investigated throughout the acute infections. We observed Th1- and Th2-type cytokine responses beginning in the prodromal phase, and late inflammatory responses were shared between the wild-type infections.
OriginalsprogEngelsk
TidsskriftJournal of General Virology
Vol/bind90
Sider (fra-til)2157-2165
Antal sider9
ISSN0022-1317
DOI
StatusUdgivet - 2009

ID: 13413338