Oromandibular dystonia, mental distress and oro-facial dysfunction: a follow-up 8-10 years after start of treatment with botulinum toxin

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Merete Bakke, Sara Baram, Torben Dalager, Heidi Bryde Biernat, Eigild Møller

Background: Oromandibular dystonia (OMD) with involuntary jaw and tongue movements may be misdiagnosed as temporomandibular disorders (TMD) and because of the complex muscle activity and involvement of several small muscles, OMD is also considered difficult to treat.Objectives: The aim was to evaluate OMD in patients 8‐10 years after start of treatment with botulinum toxin (BoNT) by self‐reported and standardised global scales and questionnaires.Methods: Of 21 previously reported patients with OMD, 14 responded to a mailhealth questionnaire to describe the disease course and treatment effect as well as the overall impact of OMD by a visual analogue scale (VAS), the Patient HealthQuestionnaire (PHQ) for depression and anxiety, and the Jaw Functional Limitation Scale (JFLS). The results were analysed with non‐parametric statistical analysis (Wilcoxon matched‐pairs test and Spearman’s rank‐order correlations).Results: The OMD was still present in 13 patients. In nine patients, the BoNT treatment had continued as monotherapy or combined with oral medication. VAS for OMD was significantly reduced (P < 0.04) over the years, and most patients felt improvement from the treatment. However, the patients had still some functional limitations, typically regarding jaw mobility and communication, and both JFLS and mental distress (PHQ) were significantly correlated with the OMD VAS (rS 0.77 and 0.74).Conclusion: The results showed marked reduction of the experienced OMD withtreatment and over time, and also stressed similarities between OMD and TMD. Both dentists and neurologists should be aware of this overlap and reduce misdiagnosis by applying an interdisciplinary approach.
OriginalsprogEngelsk
TidsskriftJournal of Oral Rehabilitation
Vol/bind46
Udgave nummer5
Sider (fra-til)441-449
Antal sider9
ISSN0305-182X
DOI
StatusUdgivet - 2019

ID: 203376756