Peptoid-Peptide hybrid backbone architectures

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Peptidomimetic oligomers and foldamers have received considerable attention for over a decade, with beta-peptides and the so-called peptoids (N-alkylglycine oligomers) representing prominent examples of such architectures. Lately, hybrid or mixed backbones consisting of both alpha- and beta-amino acids (alpha/beta-peptides) have been investigated in some detail as well. The present Minireview is a survey of the literature concerning hybrid structures of alpha-amino acids and peptoids, including beta-peptoids (N-alkyl-beta-alanine oligomers), and is intended to give an overview of this area of research within the field of peptidomimetic science.
Udgave nummer2
Sider (fra-til)152-160
StatusUdgivet - 25 jan. 2010

Bibliografisk note

Keywords: foldamers, hybrid backbones, medicinal chemistry, peptidomimetics, peptoids

ID: 33701810