Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors reverses subcronic PCP-induced deficits in the novel object recognition task in rats

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Standard

Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors reverses subcronic PCP-induced deficits in the novel object recognition task in rats. / Nielsen, Trine Damgaard; Larsen, Dorrit Bjerg ; Hansen, Suzanne Lisbet; Grayson, Ben; Neill, Jo C.; Plath, Niels.

I: Behavioural Brain Research, Bind 207, Nr. 1, 11.02.2010, s. 144-150.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Harvard

Nielsen, TD, Larsen, DB, Hansen, SL, Grayson, B, Neill, JC & Plath, N 2010, 'Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors reverses subcronic PCP-induced deficits in the novel object recognition task in rats', Behavioural Brain Research, bind 207, nr. 1, s. 144-150. https://doi.org/10.1016/j.bbr.2009.09.048

APA

Nielsen, T. D., Larsen, D. B., Hansen, S. L., Grayson, B., Neill, J. C., & Plath, N. (2010). Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors reverses subcronic PCP-induced deficits in the novel object recognition task in rats. Behavioural Brain Research, 207(1), 144-150. https://doi.org/10.1016/j.bbr.2009.09.048

Vancouver

Nielsen TD, Larsen DB, Hansen SL, Grayson B, Neill JC, Plath N. Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors reverses subcronic PCP-induced deficits in the novel object recognition task in rats. Behavioural Brain Research. 2010 feb 11;207(1):144-150. https://doi.org/10.1016/j.bbr.2009.09.048

Author

Nielsen, Trine Damgaard ; Larsen, Dorrit Bjerg ; Hansen, Suzanne Lisbet ; Grayson, Ben ; Neill, Jo C. ; Plath, Niels. / Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors reverses subcronic PCP-induced deficits in the novel object recognition task in rats. I: Behavioural Brain Research. 2010 ; Bind 207, Nr. 1. s. 144-150.

Bibtex

@article{2d4db1bd78454379af315235178edc31,
title = "Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors reverses subcronic PCP-induced deficits in the novel object recognition task in rats",
abstract = "Cognitive deficits are a major clinical unmet need in schizophrenia. The psychotomimetic drug phencyclicline (PCP) is widely applied in rodents to mimic symptoms of schizophrenia, including cognitive deficits. Precious studies have shown that sub-chronic PCP induces an enduring episodic memory deficit in female Lister hooded rats in teh novel object recognition (NOR) task. Here we show that positive modulation of AMPA receptor (AMPAR) mediated glutamate transmission alleviates cognitive deficits induced by sub-chronic PCP treatment. Female Lister hooded rats were treated sub-cronically with either vehicle (0.9{\%} saline) or PCP (2mg/kg two doses per day for 7 days), followed by a 7 days washout period. 30 min prior to the acquisition trial of the NOR task animals were dosed with either vehicle, CX546 (10, 40, or 80 mg/kg) or CX516 (0.5, 2.5, 10, 40, or 80 mg/kg). Our results show that sub-cbronic PCP treatment induced a significant decrease in the discrimination index (DI) and both ampakines CX546 and CX516 were able to reverse this diruption of object memory in rats in the novel object recognition task. These data suggest that positive AMPAR modulation may represent a mechanism for treatment of cognitive deficits in schizophrenia. (C) 2009 Elsevier B.V. All rights reserved.",
keywords = "Former Faculty of Pharmaceutical Sciences, Schizophrenia, Cognition, Phencyclidine, Ampakines, Novel object recognition, Rats",
author = "Nielsen, {Trine Damgaard} and Larsen, {Dorrit Bjerg} and Hansen, {Suzanne Lisbet} and Ben Grayson and Neill, {Jo C.} and Niels Plath",
year = "2010",
month = "2",
day = "11",
doi = "10.1016/j.bbr.2009.09.048",
language = "English",
volume = "207",
pages = "144--150",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors reverses subcronic PCP-induced deficits in the novel object recognition task in rats

AU - Nielsen, Trine Damgaard

AU - Larsen, Dorrit Bjerg

AU - Hansen, Suzanne Lisbet

AU - Grayson, Ben

AU - Neill, Jo C.

AU - Plath, Niels

PY - 2010/2/11

Y1 - 2010/2/11

N2 - Cognitive deficits are a major clinical unmet need in schizophrenia. The psychotomimetic drug phencyclicline (PCP) is widely applied in rodents to mimic symptoms of schizophrenia, including cognitive deficits. Precious studies have shown that sub-chronic PCP induces an enduring episodic memory deficit in female Lister hooded rats in teh novel object recognition (NOR) task. Here we show that positive modulation of AMPA receptor (AMPAR) mediated glutamate transmission alleviates cognitive deficits induced by sub-chronic PCP treatment. Female Lister hooded rats were treated sub-cronically with either vehicle (0.9% saline) or PCP (2mg/kg two doses per day for 7 days), followed by a 7 days washout period. 30 min prior to the acquisition trial of the NOR task animals were dosed with either vehicle, CX546 (10, 40, or 80 mg/kg) or CX516 (0.5, 2.5, 10, 40, or 80 mg/kg). Our results show that sub-cbronic PCP treatment induced a significant decrease in the discrimination index (DI) and both ampakines CX546 and CX516 were able to reverse this diruption of object memory in rats in the novel object recognition task. These data suggest that positive AMPAR modulation may represent a mechanism for treatment of cognitive deficits in schizophrenia. (C) 2009 Elsevier B.V. All rights reserved.

AB - Cognitive deficits are a major clinical unmet need in schizophrenia. The psychotomimetic drug phencyclicline (PCP) is widely applied in rodents to mimic symptoms of schizophrenia, including cognitive deficits. Precious studies have shown that sub-chronic PCP induces an enduring episodic memory deficit in female Lister hooded rats in teh novel object recognition (NOR) task. Here we show that positive modulation of AMPA receptor (AMPAR) mediated glutamate transmission alleviates cognitive deficits induced by sub-chronic PCP treatment. Female Lister hooded rats were treated sub-cronically with either vehicle (0.9% saline) or PCP (2mg/kg two doses per day for 7 days), followed by a 7 days washout period. 30 min prior to the acquisition trial of the NOR task animals were dosed with either vehicle, CX546 (10, 40, or 80 mg/kg) or CX516 (0.5, 2.5, 10, 40, or 80 mg/kg). Our results show that sub-cbronic PCP treatment induced a significant decrease in the discrimination index (DI) and both ampakines CX546 and CX516 were able to reverse this diruption of object memory in rats in the novel object recognition task. These data suggest that positive AMPAR modulation may represent a mechanism for treatment of cognitive deficits in schizophrenia. (C) 2009 Elsevier B.V. All rights reserved.

KW - Former Faculty of Pharmaceutical Sciences

KW - Schizophrenia

KW - Cognition

KW - Phencyclidine

KW - Ampakines

KW - Novel object recognition

KW - Rats

U2 - 10.1016/j.bbr.2009.09.048

DO - 10.1016/j.bbr.2009.09.048

M3 - Journal article

C2 - 19822174

VL - 207

SP - 144

EP - 150

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 1

ER -

ID: 34205810