Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters. / Andersen, Jacob; Kristensen, Anders Skov; Bang-Andersen, Benny; Strømgaard, Kristian.

I: Chemical Communications, Nr. 25, 2009, s. 3677-3692.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Andersen, J, Kristensen, AS, Bang-Andersen, B & Strømgaard, K 2009, 'Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters', Chemical Communications, nr. 25, s. 3677-3692. https://doi.org/10.1039/b903035m

APA

Andersen, J., Kristensen, A. S., Bang-Andersen, B., & Strømgaard, K. (2009). Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters. Chemical Communications, (25), 3677-3692. https://doi.org/10.1039/b903035m

Vancouver

Andersen J, Kristensen AS, Bang-Andersen B, Strømgaard K. Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters. Chemical Communications. 2009;(25):3677-3692. https://doi.org/10.1039/b903035m

Author

Andersen, Jacob ; Kristensen, Anders Skov ; Bang-Andersen, Benny ; Strømgaard, Kristian. / Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters. I: Chemical Communications. 2009 ; Nr. 25. s. 3677-3692.

Bibtex

@article{622a7c900fd011df825d000ea68e967b,
title = "Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters",
abstract = "The biogenic monoamine transporters are integral membrane proteins that perform active transport of extracellular dopamine, serotonin and norepinephrine into cells. These transporters are targets for therapeutic agents such as antidepressants, as well as addictive substances such as cocaine and amphetamine. Seminal advances in the understanding of the structure and function of this transporter family have recently been accomplished by structural studies of a bacterial transporter, as well as medicinal chemistry and pharmacological studies of mammalian transporters. This feature article focuses on antidepressant drugs that act on the serotonin and/or the norepinephrine transporters. Specifically, we focus on structure-activity relationships of these drugs with emphasis on relationships between their molecular properties and the current knowledge of transporter structure.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Jacob Andersen and Kristensen, {Anders Skov} and Benny Bang-Andersen and Kristian Str{\o}mgaard",
note = "Keywords: Animals; Antidepressive Agents; Humans; Models, Molecular; Norepinephrine Plasma Membrane Transport Proteins; Serotonin Plasma Membrane Transport Proteins; Serotonin Uptake Inhibitors; Structure-Activity Relationship",
year = "2009",
doi = "10.1039/b903035m",
language = "English",
pages = "3677--3692",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "25",

}

RIS

TY - JOUR

T1 - Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters

AU - Andersen, Jacob

AU - Kristensen, Anders Skov

AU - Bang-Andersen, Benny

AU - Strømgaard, Kristian

N1 - Keywords: Animals; Antidepressive Agents; Humans; Models, Molecular; Norepinephrine Plasma Membrane Transport Proteins; Serotonin Plasma Membrane Transport Proteins; Serotonin Uptake Inhibitors; Structure-Activity Relationship

PY - 2009

Y1 - 2009

N2 - The biogenic monoamine transporters are integral membrane proteins that perform active transport of extracellular dopamine, serotonin and norepinephrine into cells. These transporters are targets for therapeutic agents such as antidepressants, as well as addictive substances such as cocaine and amphetamine. Seminal advances in the understanding of the structure and function of this transporter family have recently been accomplished by structural studies of a bacterial transporter, as well as medicinal chemistry and pharmacological studies of mammalian transporters. This feature article focuses on antidepressant drugs that act on the serotonin and/or the norepinephrine transporters. Specifically, we focus on structure-activity relationships of these drugs with emphasis on relationships between their molecular properties and the current knowledge of transporter structure.

AB - The biogenic monoamine transporters are integral membrane proteins that perform active transport of extracellular dopamine, serotonin and norepinephrine into cells. These transporters are targets for therapeutic agents such as antidepressants, as well as addictive substances such as cocaine and amphetamine. Seminal advances in the understanding of the structure and function of this transporter family have recently been accomplished by structural studies of a bacterial transporter, as well as medicinal chemistry and pharmacological studies of mammalian transporters. This feature article focuses on antidepressant drugs that act on the serotonin and/or the norepinephrine transporters. Specifically, we focus on structure-activity relationships of these drugs with emphasis on relationships between their molecular properties and the current knowledge of transporter structure.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1039/b903035m

DO - 10.1039/b903035m

M3 - Journal article

C2 - 19557250

SP - 3677

EP - 3692

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 25

ER -

ID: 17365881