Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors

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Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors. / Pinto, Andrea; Conti, Paola; Grazioso, Giovanni; Tamborini, Lucia; Madsen, Ulf; Nielsen, Birgitte; De Micheli, Carlo.

I: European Journal of Medicinal Chemistry, Bind 46, Nr. 2, 01.02.2011, s. 787-793.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Pinto, A, Conti, P, Grazioso, G, Tamborini, L, Madsen, U, Nielsen, B & De Micheli, C 2011, 'Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors', European Journal of Medicinal Chemistry, bind 46, nr. 2, s. 787-793. https://doi.org/10.1016/j.ejmech.2010.12.020

APA

Pinto, A., Conti, P., Grazioso, G., Tamborini, L., Madsen, U., Nielsen, B., & De Micheli, C. (2011). Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors. European Journal of Medicinal Chemistry, 46(2), 787-793. https://doi.org/10.1016/j.ejmech.2010.12.020

Vancouver

Pinto A, Conti P, Grazioso G, Tamborini L, Madsen U, Nielsen B o.a. Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors. European Journal of Medicinal Chemistry. 2011 feb 1;46(2):787-793. https://doi.org/10.1016/j.ejmech.2010.12.020

Author

Pinto, Andrea ; Conti, Paola ; Grazioso, Giovanni ; Tamborini, Lucia ; Madsen, Ulf ; Nielsen, Birgitte ; De Micheli, Carlo. / Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors. I: European Journal of Medicinal Chemistry. 2011 ; Bind 46, Nr. 2. s. 787-793.

Bibtex

@article{c836c439ef524b24b97bbbb541cf1bae,
title = "Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors",
abstract = "The synthesis of four new isoxazoline-based amino acids being analogues of previously described glutamate receptor ligands is reported and their affinity for ionotropic glutamate receptors is analyzed in comparison with that of selected model compounds. Molecular modelling investigations have been carried out to rationalize the interaction with the NMDA receptors.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Andrea Pinto and Paola Conti and Giovanni Grazioso and Lucia Tamborini and Ulf Madsen and Birgitte Nielsen and {De Micheli}, Carlo",
note = "Keywords: glutamic acid, ionotropic Glu receptors, isoxazoline, 1,3-dipolar cycloaddition",
year = "2011",
month = "2",
day = "1",
doi = "10.1016/j.ejmech.2010.12.020",
language = "English",
volume = "46",
pages = "787--793",
journal = "European Journal of Medicinal Chemistry",
issn = "0223-5234",
publisher = "Elsevier Masson",
number = "2",

}

RIS

TY - JOUR

T1 - Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors

AU - Pinto, Andrea

AU - Conti, Paola

AU - Grazioso, Giovanni

AU - Tamborini, Lucia

AU - Madsen, Ulf

AU - Nielsen, Birgitte

AU - De Micheli, Carlo

N1 - Keywords: glutamic acid, ionotropic Glu receptors, isoxazoline, 1,3-dipolar cycloaddition

PY - 2011/2/1

Y1 - 2011/2/1

N2 - The synthesis of four new isoxazoline-based amino acids being analogues of previously described glutamate receptor ligands is reported and their affinity for ionotropic glutamate receptors is analyzed in comparison with that of selected model compounds. Molecular modelling investigations have been carried out to rationalize the interaction with the NMDA receptors.

AB - The synthesis of four new isoxazoline-based amino acids being analogues of previously described glutamate receptor ligands is reported and their affinity for ionotropic glutamate receptors is analyzed in comparison with that of selected model compounds. Molecular modelling investigations have been carried out to rationalize the interaction with the NMDA receptors.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1016/j.ejmech.2010.12.020

DO - 10.1016/j.ejmech.2010.12.020

M3 - Journal article

C2 - 21220180

VL - 46

SP - 787

EP - 793

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

SN - 0223-5234

IS - 2

ER -

ID: 33687646