Computer science, robotics and AI have all developed rapidly in recent years, bringing profound changes to all aspects of human life. However, the emergence and proliferation of these new technologies has not occurred within the bounds of traditional organizational, ethical and regulatory systems. We have reached an inflection point, where we need to pursue new business models and normative frameworks to underpin these fast-developing technologies. This introductory chapter briefly maps the evolution of these different technologies and argues for a new, more forward-oriented approach to the business and normative challenges that are created. The discussion ends with a review of the chapters that comprise this volume.