ClpP-dependent and -independent activities encoded by the polycistronic clpK-encoding locus contribute to heat shock survival in Klebsiella pneumoniae

Research output: Contribution to journalJournal articlepeer-review

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ClpP-dependent and -independent activities encoded by the polycistronic clpK-encoding locus contribute to heat shock survival in Klebsiella pneumoniae. / Bojer, Martin Saxtorph; Struve, Carsten; Ingmer, Hanne; Krogfelt, Karen Angeliki.

In: Research in Microbiology, Vol. 164, No. 3, 2013, p. 205-210.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Bojer, MS, Struve, C, Ingmer, H & Krogfelt, KA 2013, 'ClpP-dependent and -independent activities encoded by the polycistronic clpK-encoding locus contribute to heat shock survival in Klebsiella pneumoniae', Research in Microbiology, vol. 164, no. 3, pp. 205-210. https://doi.org/10.1016/j.resmic.2012.11.005

APA

Bojer, M. S., Struve, C., Ingmer, H., & Krogfelt, K. A. (2013). ClpP-dependent and -independent activities encoded by the polycistronic clpK-encoding locus contribute to heat shock survival in Klebsiella pneumoniae. Research in Microbiology, 164(3), 205-210. https://doi.org/10.1016/j.resmic.2012.11.005

Vancouver

Bojer MS, Struve C, Ingmer H, Krogfelt KA. ClpP-dependent and -independent activities encoded by the polycistronic clpK-encoding locus contribute to heat shock survival in Klebsiella pneumoniae. Research in Microbiology. 2013;164(3):205-210. https://doi.org/10.1016/j.resmic.2012.11.005

Author

Bojer, Martin Saxtorph ; Struve, Carsten ; Ingmer, Hanne ; Krogfelt, Karen Angeliki. / ClpP-dependent and -independent activities encoded by the polycistronic clpK-encoding locus contribute to heat shock survival in Klebsiella pneumoniae. In: Research in Microbiology. 2013 ; Vol. 164, No. 3. pp. 205-210.

Bibtex

@article{e7ecc27fea32429f98b32cd0ca78028c,
title = "ClpP-dependent and -independent activities encoded by the polycistronic clpK-encoding locus contribute to heat shock survival in Klebsiella pneumoniae",
abstract = "The family of Clp ATPases plays an important role in bacterial physiology. Here we characterize the genetic locus encompassing a newly described plasmid-encoded ClpK protein protecting Klebsiella pneumoniae cells during heat shock. We demonstrate that the clpK gene is located in a polycistronic operon and that the variable downstream gene content correlates with heat-resistant phenotypes of different isolates. ClpK is encoded by a multifunctional transcriptional unit characterized by both ClpP-dependent and -independent activities. Notably, our data show that ClpP is indispensible for thermoprotection exerted by ClpK alone, suggesting that ClpK is a new member of the family of ClpP-interacting Clp ATPases.",
keywords = "Former LIFE faculty, Klebsiella pneumoniae, Clp ATPase, ClpK, Heat resistance, ClpP, sHSP",
author = "Bojer, {Martin Saxtorph} and Carsten Struve and Hanne Ingmer and Krogfelt, {Karen Angeliki}",
note = "Copyright {\textcopyright} 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.",
year = "2013",
doi = "10.1016/j.resmic.2012.11.005",
language = "English",
volume = "164",
pages = "205--210",
journal = "Research in Microbiology",
issn = "0923-2508",
publisher = "Elsevier Masson",
number = "3",

}

RIS

TY - JOUR

T1 - ClpP-dependent and -independent activities encoded by the polycistronic clpK-encoding locus contribute to heat shock survival in Klebsiella pneumoniae

AU - Bojer, Martin Saxtorph

AU - Struve, Carsten

AU - Ingmer, Hanne

AU - Krogfelt, Karen Angeliki

N1 - Copyright © 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

PY - 2013

Y1 - 2013

N2 - The family of Clp ATPases plays an important role in bacterial physiology. Here we characterize the genetic locus encompassing a newly described plasmid-encoded ClpK protein protecting Klebsiella pneumoniae cells during heat shock. We demonstrate that the clpK gene is located in a polycistronic operon and that the variable downstream gene content correlates with heat-resistant phenotypes of different isolates. ClpK is encoded by a multifunctional transcriptional unit characterized by both ClpP-dependent and -independent activities. Notably, our data show that ClpP is indispensible for thermoprotection exerted by ClpK alone, suggesting that ClpK is a new member of the family of ClpP-interacting Clp ATPases.

AB - The family of Clp ATPases plays an important role in bacterial physiology. Here we characterize the genetic locus encompassing a newly described plasmid-encoded ClpK protein protecting Klebsiella pneumoniae cells during heat shock. We demonstrate that the clpK gene is located in a polycistronic operon and that the variable downstream gene content correlates with heat-resistant phenotypes of different isolates. ClpK is encoded by a multifunctional transcriptional unit characterized by both ClpP-dependent and -independent activities. Notably, our data show that ClpP is indispensible for thermoprotection exerted by ClpK alone, suggesting that ClpK is a new member of the family of ClpP-interacting Clp ATPases.

KW - Former LIFE faculty

KW - Klebsiella pneumoniae

KW - Clp ATPase

KW - ClpK

KW - Heat resistance

KW - ClpP

KW - sHSP

U2 - 10.1016/j.resmic.2012.11.005

DO - 10.1016/j.resmic.2012.11.005

M3 - Journal article

C2 - 23201206

VL - 164

SP - 205

EP - 210

JO - Research in Microbiology

JF - Research in Microbiology

SN - 0923-2508

IS - 3

ER -

ID: 91895808