Influence of Infant Cleft Dimensions on Velopharyngeal Function in 5-Year-Old Danish Children Born With Unilateral Cleft Lip and Palate

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Influence of Infant Cleft Dimensions on Velopharyngeal Function in 5-Year-Old Danish Children Born With Unilateral Cleft Lip and Palate. / Botticelli, Susanna; Küseler, Annelise; Mølsted, Kirsten ; Søgaard Andersen, Helene ; Boers, Maria; Schoeps, Antje; Emborg, Berit Kildegaard; Kisling-Møller, Mia; Klit Petersen, Thomas ; Andersen, Mikael; Willadsen, Elisabeth.

In: The Cleft Palate-Craniofacial Journal, Vol. 57, No. 4, 2020, p. 420-429.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Botticelli, S, Küseler, A, Mølsted, K, Søgaard Andersen, H, Boers, M, Schoeps, A, Emborg, BK, Kisling-Møller, M, Klit Petersen, T, Andersen, M & Willadsen, E 2020, 'Influence of Infant Cleft Dimensions on Velopharyngeal Function in 5-Year-Old Danish Children Born With Unilateral Cleft Lip and Palate', The Cleft Palate-Craniofacial Journal, vol. 57, no. 4, pp. 420-429. https://doi.org/10.1177/1055665619874143

APA

Botticelli, S., Küseler, A., Mølsted, K., Søgaard Andersen, H., Boers, M., Schoeps, A., ... Willadsen, E. (2020). Influence of Infant Cleft Dimensions on Velopharyngeal Function in 5-Year-Old Danish Children Born With Unilateral Cleft Lip and Palate. The Cleft Palate-Craniofacial Journal, 57(4), 420-429. https://doi.org/10.1177/1055665619874143

Vancouver

Botticelli S, Küseler A, Mølsted K, Søgaard Andersen H, Boers M, Schoeps A et al. Influence of Infant Cleft Dimensions on Velopharyngeal Function in 5-Year-Old Danish Children Born With Unilateral Cleft Lip and Palate. The Cleft Palate-Craniofacial Journal. 2020;57(4):420-429. https://doi.org/10.1177/1055665619874143

Author

Botticelli, Susanna ; Küseler, Annelise ; Mølsted, Kirsten ; Søgaard Andersen, Helene ; Boers, Maria ; Schoeps, Antje ; Emborg, Berit Kildegaard ; Kisling-Møller, Mia ; Klit Petersen, Thomas ; Andersen, Mikael ; Willadsen, Elisabeth. / Influence of Infant Cleft Dimensions on Velopharyngeal Function in 5-Year-Old Danish Children Born With Unilateral Cleft Lip and Palate. In: The Cleft Palate-Craniofacial Journal. 2020 ; Vol. 57, No. 4. pp. 420-429.

Bibtex

@article{a5b8bf9db2af4e4b9d559d8ec0444f9e,
title = "Influence of Infant Cleft Dimensions on Velopharyngeal Function in 5-Year-Old Danish Children Born With Unilateral Cleft Lip and Palate",
abstract = "Aim:To examine the association of cleft severity at infancy and velopharyngeal competence in preschool children with unilateral cleft lip and palate operated with early or delayed hard palate repair.Design:Subgroup analysis within a multicenter randomized controlled trial of primary surgery (Scandcleft).Setting:Tertiary health care. One surgical center.Patients and Methods:One hundred twenty-five infants received cheilo-rhinoplasty and soft palate repair at age 3 to 4 months and were randomized to hard palate closure at age 12 or 36 months. Cleft size and cleft morphology were measured 3 dimensionally on digital models, obtained by laser surface scanning of preoperative plaster models (mean age: 1.8 months).Main outcome measurements:Velopharyngeal competence (VPC) and hypernasality assessed from a naming test (VPC-Sum) and connected speech (VPC-Rate). In both scales, higher scores indicated a more severe velopharyngeal insufficiency.Results:No difference between surgical groups was shown. A low positive correlation was found between posterior cleft width and VPC-Rate (Spearman = .23; P = .025). The role of the covariate “cleft size at tuberosity level” was confirmed in an ordinal logistic regression model (odds ratio [OR] = 1.17; 95{\%} confidence interval [CI]:1.01-1.35). A low negative correlation was shown between anteroposterior palatal length and VPC-Sum (Spearman = −.27; P = .004) and confirmed by the pooled scores VPC-Pooled (OR = 0.82; 95{\%} CI: 0.69-0.98) and VPC-Dichotomic (OR = 0.82; 95{\%} CI: 0.68-0.99).Conclusions:Posterior cleft dimensions can be a modest indicator for the prognosis of velopharyngeal function at age 5 years, when the soft palate is closed first, independently on the timing of hard palate repair. Antero-posterior palatal length seems to protect from velopharyngeal insufficiency and hypernasality. However, the association found was significant but low.Keywords nonsyndromic clefting, speech development, velopharyngeal function, hard palate, surgical technique",
author = "Susanna Botticelli and Annelise K{\"u}seler and Kirsten M{\o}lsted and {S{\o}gaard Andersen}, Helene and Maria Boers and Antje Schoeps and Emborg, {Berit Kildegaard} and Mia Kisling-M{\o}ller and {Klit Petersen}, Thomas and Mikael Andersen and Elisabeth Willadsen",
year = "2020",
doi = "10.1177/1055665619874143",
language = "English",
volume = "57",
pages = "420--429",
journal = "Cleft Palate - Craniofacial Journal",
issn = "1055-6656",
publisher = "Allen Press Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Influence of Infant Cleft Dimensions on Velopharyngeal Function in 5-Year-Old Danish Children Born With Unilateral Cleft Lip and Palate

AU - Botticelli, Susanna

AU - Küseler, Annelise

AU - Mølsted, Kirsten

AU - Søgaard Andersen, Helene

AU - Boers, Maria

AU - Schoeps, Antje

AU - Emborg, Berit Kildegaard

AU - Kisling-Møller, Mia

AU - Klit Petersen, Thomas

AU - Andersen, Mikael

AU - Willadsen, Elisabeth

PY - 2020

Y1 - 2020

N2 - Aim:To examine the association of cleft severity at infancy and velopharyngeal competence in preschool children with unilateral cleft lip and palate operated with early or delayed hard palate repair.Design:Subgroup analysis within a multicenter randomized controlled trial of primary surgery (Scandcleft).Setting:Tertiary health care. One surgical center.Patients and Methods:One hundred twenty-five infants received cheilo-rhinoplasty and soft palate repair at age 3 to 4 months and were randomized to hard palate closure at age 12 or 36 months. Cleft size and cleft morphology were measured 3 dimensionally on digital models, obtained by laser surface scanning of preoperative plaster models (mean age: 1.8 months).Main outcome measurements:Velopharyngeal competence (VPC) and hypernasality assessed from a naming test (VPC-Sum) and connected speech (VPC-Rate). In both scales, higher scores indicated a more severe velopharyngeal insufficiency.Results:No difference between surgical groups was shown. A low positive correlation was found between posterior cleft width and VPC-Rate (Spearman = .23; P = .025). The role of the covariate “cleft size at tuberosity level” was confirmed in an ordinal logistic regression model (odds ratio [OR] = 1.17; 95% confidence interval [CI]:1.01-1.35). A low negative correlation was shown between anteroposterior palatal length and VPC-Sum (Spearman = −.27; P = .004) and confirmed by the pooled scores VPC-Pooled (OR = 0.82; 95% CI: 0.69-0.98) and VPC-Dichotomic (OR = 0.82; 95% CI: 0.68-0.99).Conclusions:Posterior cleft dimensions can be a modest indicator for the prognosis of velopharyngeal function at age 5 years, when the soft palate is closed first, independently on the timing of hard palate repair. Antero-posterior palatal length seems to protect from velopharyngeal insufficiency and hypernasality. However, the association found was significant but low.Keywords nonsyndromic clefting, speech development, velopharyngeal function, hard palate, surgical technique

AB - Aim:To examine the association of cleft severity at infancy and velopharyngeal competence in preschool children with unilateral cleft lip and palate operated with early or delayed hard palate repair.Design:Subgroup analysis within a multicenter randomized controlled trial of primary surgery (Scandcleft).Setting:Tertiary health care. One surgical center.Patients and Methods:One hundred twenty-five infants received cheilo-rhinoplasty and soft palate repair at age 3 to 4 months and were randomized to hard palate closure at age 12 or 36 months. Cleft size and cleft morphology were measured 3 dimensionally on digital models, obtained by laser surface scanning of preoperative plaster models (mean age: 1.8 months).Main outcome measurements:Velopharyngeal competence (VPC) and hypernasality assessed from a naming test (VPC-Sum) and connected speech (VPC-Rate). In both scales, higher scores indicated a more severe velopharyngeal insufficiency.Results:No difference between surgical groups was shown. A low positive correlation was found between posterior cleft width and VPC-Rate (Spearman = .23; P = .025). The role of the covariate “cleft size at tuberosity level” was confirmed in an ordinal logistic regression model (odds ratio [OR] = 1.17; 95% confidence interval [CI]:1.01-1.35). A low negative correlation was shown between anteroposterior palatal length and VPC-Sum (Spearman = −.27; P = .004) and confirmed by the pooled scores VPC-Pooled (OR = 0.82; 95% CI: 0.69-0.98) and VPC-Dichotomic (OR = 0.82; 95% CI: 0.68-0.99).Conclusions:Posterior cleft dimensions can be a modest indicator for the prognosis of velopharyngeal function at age 5 years, when the soft palate is closed first, independently on the timing of hard palate repair. Antero-posterior palatal length seems to protect from velopharyngeal insufficiency and hypernasality. However, the association found was significant but low.Keywords nonsyndromic clefting, speech development, velopharyngeal function, hard palate, surgical technique

U2 - 10.1177/1055665619874143

DO - 10.1177/1055665619874143

M3 - Journal article

VL - 57

SP - 420

EP - 429

JO - Cleft Palate - Craniofacial Journal

JF - Cleft Palate - Craniofacial Journal

SN - 1055-6656

IS - 4

ER -

ID: 226222656