Scandcleft Project, Trial 1: Comparison of Speech Outcome in Relation to Timing of Hard Palate Closure in 5-Year-Olds With UCLP

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Scandcleft Project, Trial 1: Comparison of Speech Outcome in Relation to Timing of Hard Palate Closure in 5-Year-Olds With UCLP. / Willadsen, Elisabeth; Lohmander, Anette; Persson , Christina; Boers, Maria; Kisling-Møller, Mia; Havstam, Christina; Elander, Anna; Andersen, Mikael.

I: Cleft Palate - Craniofacial Journal, Bind 56, 06.2019, s. 1276-1286.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Willadsen, E, Lohmander, A, Persson , C, Boers, M, Kisling-Møller, M, Havstam, C, Elander, A & Andersen, M 2019, 'Scandcleft Project, Trial 1: Comparison of Speech Outcome in Relation to Timing of Hard Palate Closure in 5-Year-Olds With UCLP', Cleft Palate - Craniofacial Journal, bind 56, s. 1276-1286. https://doi.org/10.1177/1055665619854632

APA

Willadsen, E., Lohmander, A., Persson , C., Boers, M., Kisling-Møller, M., Havstam, C., Elander, A., & Andersen, M. (2019). Scandcleft Project, Trial 1: Comparison of Speech Outcome in Relation to Timing of Hard Palate Closure in 5-Year-Olds With UCLP. Cleft Palate - Craniofacial Journal, 56, 1276-1286. https://doi.org/10.1177/1055665619854632

Vancouver

Willadsen E, Lohmander A, Persson C, Boers M, Kisling-Møller M, Havstam C o.a. Scandcleft Project, Trial 1: Comparison of Speech Outcome in Relation to Timing of Hard Palate Closure in 5-Year-Olds With UCLP. Cleft Palate - Craniofacial Journal. 2019 jun.;56:1276-1286. https://doi.org/10.1177/1055665619854632

Author

Willadsen, Elisabeth ; Lohmander, Anette ; Persson , Christina ; Boers, Maria ; Kisling-Møller, Mia ; Havstam, Christina ; Elander, Anna ; Andersen, Mikael. / Scandcleft Project, Trial 1: Comparison of Speech Outcome in Relation to Timing of Hard Palate Closure in 5-Year-Olds With UCLP. I: Cleft Palate - Craniofacial Journal. 2019 ; Bind 56. s. 1276-1286.

Bibtex

@article{f3100287eb254a3dac49538ca09faaa2,
title = "Scandcleft Project, Trial 1: Comparison of Speech Outcome in Relation to Timing of Hard Palate Closure in 5-Year-Olds With UCLP",
abstract = "AbstractObjective:To compare in-depth speech results in Scandcleft Trial 1 as well as reference data from peers without cleft palate (CP).Design:A prospective randomized clinical trial.Setting:A Danish and a Swedish CP center.Participants:143 of 148 randomized 5-year-olds with unilateral cleft lip and palate. All received lip and velum closure at 4 months, and hard palate closure at 12 months (arm A) or 36 months (arm B).Main Outcome Measures:A composite measure based on velopharyngeal competence (VPC) or velopharyngeal incompetence (VPI), an overall assessment of VPC from connected speech (VPC-Rate), Percentage of Consonants Correct (PCC-score), and consonant errors. Speech therapy visits, average hearing thresholds, and secondary pharyngeal surgeries documented burden of treatment.Results:Across the trial, 61.5% demonstrated VPC and 38.5% VPI. Twenty-two percent of participants achieved age appropriate PCC-scores. There were no statistically significant differences between arms or centers for these measures. In the Danish center, arm B: achieved lower PCC-scores (P = .01); obtained PCC-scores without s-errors below 79% (P = .002); produced ≥3 active oral cleft speech characteristics (P = .004) than arm A. In both centers, arm B attended more speech visits.Conclusions:At age 5, differences between centers and treatment arms were not statistically significant for VPC/VPI, but consonant proficiency differed between treatment arms in the Danish center. Poor speech outcomes were seen for both treatment arms. Variations between centers were observed. As the Swedish center had few participants, intercenter comparisons should be interpreted with caution.Keywords RCT, 2-stage procedure, velopharyngeal function, consonant proficiency",
author = "Elisabeth Willadsen and Anette Lohmander and Christina Persson and Maria Boers and Mia Kisling-M{\o}ller and Christina Havstam and Anna Elander and Mikael Andersen",
year = "2019",
month = jun,
doi = "10.1177/1055665619854632",
language = "English",
volume = "56",
pages = "1276--1286",
journal = "Cleft Palate - Craniofacial Journal",
issn = "1055-6656",
publisher = "Allen Press Inc.",

}

RIS

TY - JOUR

T1 - Scandcleft Project, Trial 1: Comparison of Speech Outcome in Relation to Timing of Hard Palate Closure in 5-Year-Olds With UCLP

AU - Willadsen, Elisabeth

AU - Lohmander, Anette

AU - Persson , Christina

AU - Boers, Maria

AU - Kisling-Møller, Mia

AU - Havstam, Christina

AU - Elander, Anna

AU - Andersen, Mikael

PY - 2019/6

Y1 - 2019/6

N2 - AbstractObjective:To compare in-depth speech results in Scandcleft Trial 1 as well as reference data from peers without cleft palate (CP).Design:A prospective randomized clinical trial.Setting:A Danish and a Swedish CP center.Participants:143 of 148 randomized 5-year-olds with unilateral cleft lip and palate. All received lip and velum closure at 4 months, and hard palate closure at 12 months (arm A) or 36 months (arm B).Main Outcome Measures:A composite measure based on velopharyngeal competence (VPC) or velopharyngeal incompetence (VPI), an overall assessment of VPC from connected speech (VPC-Rate), Percentage of Consonants Correct (PCC-score), and consonant errors. Speech therapy visits, average hearing thresholds, and secondary pharyngeal surgeries documented burden of treatment.Results:Across the trial, 61.5% demonstrated VPC and 38.5% VPI. Twenty-two percent of participants achieved age appropriate PCC-scores. There were no statistically significant differences between arms or centers for these measures. In the Danish center, arm B: achieved lower PCC-scores (P = .01); obtained PCC-scores without s-errors below 79% (P = .002); produced ≥3 active oral cleft speech characteristics (P = .004) than arm A. In both centers, arm B attended more speech visits.Conclusions:At age 5, differences between centers and treatment arms were not statistically significant for VPC/VPI, but consonant proficiency differed between treatment arms in the Danish center. Poor speech outcomes were seen for both treatment arms. Variations between centers were observed. As the Swedish center had few participants, intercenter comparisons should be interpreted with caution.Keywords RCT, 2-stage procedure, velopharyngeal function, consonant proficiency

AB - AbstractObjective:To compare in-depth speech results in Scandcleft Trial 1 as well as reference data from peers without cleft palate (CP).Design:A prospective randomized clinical trial.Setting:A Danish and a Swedish CP center.Participants:143 of 148 randomized 5-year-olds with unilateral cleft lip and palate. All received lip and velum closure at 4 months, and hard palate closure at 12 months (arm A) or 36 months (arm B).Main Outcome Measures:A composite measure based on velopharyngeal competence (VPC) or velopharyngeal incompetence (VPI), an overall assessment of VPC from connected speech (VPC-Rate), Percentage of Consonants Correct (PCC-score), and consonant errors. Speech therapy visits, average hearing thresholds, and secondary pharyngeal surgeries documented burden of treatment.Results:Across the trial, 61.5% demonstrated VPC and 38.5% VPI. Twenty-two percent of participants achieved age appropriate PCC-scores. There were no statistically significant differences between arms or centers for these measures. In the Danish center, arm B: achieved lower PCC-scores (P = .01); obtained PCC-scores without s-errors below 79% (P = .002); produced ≥3 active oral cleft speech characteristics (P = .004) than arm A. In both centers, arm B attended more speech visits.Conclusions:At age 5, differences between centers and treatment arms were not statistically significant for VPC/VPI, but consonant proficiency differed between treatment arms in the Danish center. Poor speech outcomes were seen for both treatment arms. Variations between centers were observed. As the Swedish center had few participants, intercenter comparisons should be interpreted with caution.Keywords RCT, 2-stage procedure, velopharyngeal function, consonant proficiency

U2 - 10.1177/1055665619854632

DO - 10.1177/1055665619854632

M3 - Journal article

C2 - 31189334

VL - 56

SP - 1276

EP - 1286

JO - Cleft Palate - Craniofacial Journal

JF - Cleft Palate - Craniofacial Journal

SN - 1055-6656

ER -

ID: 223508459