The penetration of cefazolin, erythromycin and methicillin into human bone tissue.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

The penetration of cefazolin, erythromycin and methicillin into human bone tissue. / Sørensen, T S; Colding, H; Schroeder, E; Rosdahl, V T.

I: Acta Orthopaedica (Print Edition), Bind 49, Nr. 6, 1978, s. 549-53.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Sørensen, TS, Colding, H, Schroeder, E & Rosdahl, VT 1978, 'The penetration of cefazolin, erythromycin and methicillin into human bone tissue.', Acta Orthopaedica (Print Edition), bind 49, nr. 6, s. 549-53.

APA

Sørensen, T. S., Colding, H., Schroeder, E., & Rosdahl, V. T. (1978). The penetration of cefazolin, erythromycin and methicillin into human bone tissue. Acta Orthopaedica (Print Edition), 49(6), 549-53.

Vancouver

Sørensen TS, Colding H, Schroeder E, Rosdahl VT. The penetration of cefazolin, erythromycin and methicillin into human bone tissue. Acta Orthopaedica (Print Edition). 1978;49(6):549-53.

Author

Sørensen, T S ; Colding, H ; Schroeder, E ; Rosdahl, V T. / The penetration of cefazolin, erythromycin and methicillin into human bone tissue. I: Acta Orthopaedica (Print Edition). 1978 ; Bind 49, Nr. 6. s. 549-53.

Bibtex

@article{62a2eaa0b55311ddb04f000ea68e967b,
title = "The penetration of cefazolin, erythromycin and methicillin into human bone tissue.",
abstract = "The penetration of cefazolin, erythromycin and methicillin into normal bone was studied in 20 patients undergoing surgery for fracture in the trochanteric region of the femur. The antibiotic concentrations were determined in serum, bone marrow, and cancellous and cortical bone. For all three antibiotics the bone marrow concentrations were of the same order of magnitude as the serum concentrations. In the eight patients receiving erythromycin, detectable concentrations were found in all the cancellous bone specimens (ranging from 1/7 to 1/2 of the serum concentration) and in three cortical bone specimens (ranging from 1/50 to 1/5 of the serum concentration). In the six patients receiving cefazolin, a detectable concentration was found in only one cancellous bone sample. In the six patients receiving methicillin, detectable concentrations were found only in the blood contaminated specimens of one cancellous and two cortical bone samples. However, by the method used, the recoveries of standard solutions of methicillin in cancellous and cortical bone were about 50 per cent and 15 per cent, respectively.",
author = "S{\o}rensen, {T S} and H Colding and E Schroeder and Rosdahl, {V T}",
note = "Keywords: Aged; Bone Marrow; Bone and Bones; Cefazolin; Cephalosporins; Erythromycin; Female; Femoral Fractures; Fracture Fixation, Internal; Humans; Male; Methicillin; Middle Aged; Surgical Wound Infection",
year = "1978",
language = "English",
volume = "49",
pages = "549--53",
journal = "Acta Orthopaedica",
issn = "1745-3674",
publisher = "Taylor & Francis",
number = "6",

}

RIS

TY - JOUR

T1 - The penetration of cefazolin, erythromycin and methicillin into human bone tissue.

AU - Sørensen, T S

AU - Colding, H

AU - Schroeder, E

AU - Rosdahl, V T

N1 - Keywords: Aged; Bone Marrow; Bone and Bones; Cefazolin; Cephalosporins; Erythromycin; Female; Femoral Fractures; Fracture Fixation, Internal; Humans; Male; Methicillin; Middle Aged; Surgical Wound Infection

PY - 1978

Y1 - 1978

N2 - The penetration of cefazolin, erythromycin and methicillin into normal bone was studied in 20 patients undergoing surgery for fracture in the trochanteric region of the femur. The antibiotic concentrations were determined in serum, bone marrow, and cancellous and cortical bone. For all three antibiotics the bone marrow concentrations were of the same order of magnitude as the serum concentrations. In the eight patients receiving erythromycin, detectable concentrations were found in all the cancellous bone specimens (ranging from 1/7 to 1/2 of the serum concentration) and in three cortical bone specimens (ranging from 1/50 to 1/5 of the serum concentration). In the six patients receiving cefazolin, a detectable concentration was found in only one cancellous bone sample. In the six patients receiving methicillin, detectable concentrations were found only in the blood contaminated specimens of one cancellous and two cortical bone samples. However, by the method used, the recoveries of standard solutions of methicillin in cancellous and cortical bone were about 50 per cent and 15 per cent, respectively.

AB - The penetration of cefazolin, erythromycin and methicillin into normal bone was studied in 20 patients undergoing surgery for fracture in the trochanteric region of the femur. The antibiotic concentrations were determined in serum, bone marrow, and cancellous and cortical bone. For all three antibiotics the bone marrow concentrations were of the same order of magnitude as the serum concentrations. In the eight patients receiving erythromycin, detectable concentrations were found in all the cancellous bone specimens (ranging from 1/7 to 1/2 of the serum concentration) and in three cortical bone specimens (ranging from 1/50 to 1/5 of the serum concentration). In the six patients receiving cefazolin, a detectable concentration was found in only one cancellous bone sample. In the six patients receiving methicillin, detectable concentrations were found only in the blood contaminated specimens of one cancellous and two cortical bone samples. However, by the method used, the recoveries of standard solutions of methicillin in cancellous and cortical bone were about 50 per cent and 15 per cent, respectively.

M3 - Journal article

C2 - 735781

VL - 49

SP - 549

EP - 553

JO - Acta Orthopaedica

JF - Acta Orthopaedica

SN - 1745-3674

IS - 6

ER -

ID: 8670240