TY - JOUR

T1 - Can the lateralized readiness potential detect suppressed manual responses to pure tones?

AU - Morris, David Jackson

AU - Brännström, K. Jonas

AU - Sabourin, Catherine

PY - 2020

Y1 - 2020

N2 - BackgroundWillfully not responding to auditory stimuli hampers accurate behavioral measurements. An objective measure of covert manual suppression recorded during response tasks may be useful to assess the veracity of responses to stimuli.PurposeTo investigate whether the Lateralized Readiness Potential (LRP), an electrophysiological measure of corticomotor response and suppression, may be of use in determining when subjects hear but do not respond to pure tones.Research DesignWithin-subject repeated measures with a Go-NoGo paradigm. Study SampleFive males and five females (mean age=38.8, SD=8.8) underwent electrophysiology testing. All had normal hearing, except one.InterventionSubjects were tested in a condition where they consistently responded to tonal stimuli, and in a condition where intensity cued whether they should respond or not. Scalp-recorded cortical potentials and behavioral responses were recorded, along with a question that probed the perceived effort required to suppress responses to the stimuli.Data Collection and AnalysisElectrophysiology data was processed with Independent Component Analysis and epoch-based artifact rejection. Averaged group and individual LRPs were calculated.ResultsGroup averaged waveforms show that suppressed responses, cued by NoGo stimuli, diverge positively at approximately 300 ms poststimulus, when compared to performed (Go) responses. LRPs were comparable when Go responses were recorded in a separate condition in which subjects responded to all stimuli, and when Go and NoGo trials were included in the same condition. The LRP was not observed in one subject.ConclusionsSubsequent to further investigation, the LRP may prove suitable in assessing the suppression of responses to audiometric stimuli, and thereby useful in cases where functional hearing loss is suspected. Keywords: functional hearing loss; electrophysiology; lateralized readiness potentialAbbreviations: EEG= Electroencephalography; kΩ=kilo ohms; LRP=Lateralized Readiness Potential; μV=micro Volts

AB - BackgroundWillfully not responding to auditory stimuli hampers accurate behavioral measurements. An objective measure of covert manual suppression recorded during response tasks may be useful to assess the veracity of responses to stimuli.PurposeTo investigate whether the Lateralized Readiness Potential (LRP), an electrophysiological measure of corticomotor response and suppression, may be of use in determining when subjects hear but do not respond to pure tones.Research DesignWithin-subject repeated measures with a Go-NoGo paradigm. Study SampleFive males and five females (mean age=38.8, SD=8.8) underwent electrophysiology testing. All had normal hearing, except one.InterventionSubjects were tested in a condition where they consistently responded to tonal stimuli, and in a condition where intensity cued whether they should respond or not. Scalp-recorded cortical potentials and behavioral responses were recorded, along with a question that probed the perceived effort required to suppress responses to the stimuli.Data Collection and AnalysisElectrophysiology data was processed with Independent Component Analysis and epoch-based artifact rejection. Averaged group and individual LRPs were calculated.ResultsGroup averaged waveforms show that suppressed responses, cued by NoGo stimuli, diverge positively at approximately 300 ms poststimulus, when compared to performed (Go) responses. LRPs were comparable when Go responses were recorded in a separate condition in which subjects responded to all stimuli, and when Go and NoGo trials were included in the same condition. The LRP was not observed in one subject.ConclusionsSubsequent to further investigation, the LRP may prove suitable in assessing the suppression of responses to audiometric stimuli, and thereby useful in cases where functional hearing loss is suspected. Keywords: functional hearing loss; electrophysiology; lateralized readiness potentialAbbreviations: EEG= Electroencephalography; kΩ=kilo ohms; LRP=Lateralized Readiness Potential; μV=micro Volts

U2 - 10.3766/jaaa.18069

DO - 10.3766/jaaa.18069

M3 - Journal article

C2 - 31241452

VL - 31

SP - 61

EP - 68

JO - Journal of the American Academy of Audiology

JF - Journal of the American Academy of Audiology

SN - 1050-0545

IS - 1

ER -