Developmental language disorder – a comprehensive study of more than 46,000 individuals

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

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Developmental language disorder – a comprehensive study of more than 46,000 individuals. / Nudel, Ron; Christensen, Rikke Vang; Kalnak, Nelli; Schwinn, Michael; Banasik, Karina; Dinh, Khoa Manh; Erikstrup, Christian; Pedersen, Ole Birger; Burgdorf, Kristoffer Sølvsten; Ullum, Henrik; Ostrowski, Sisse Rye; Hansen, Thomas Folkmann; Werge, Thomas; DBDS Genomic Consortium.

I: Psychiatry Research, Bind 323, 115171, 2023.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Nudel, R, Christensen, RV, Kalnak, N, Schwinn, M, Banasik, K, Dinh, KM, Erikstrup, C, Pedersen, OB, Burgdorf, KS, Ullum, H, Ostrowski, SR, Hansen, TF, Werge, T & DBDS Genomic Consortium 2023, 'Developmental language disorder – a comprehensive study of more than 46,000 individuals', Psychiatry Research, bind 323, 115171. https://doi.org/10.1016/j.psychres.2023.115171

APA

Nudel, R., Christensen, R. V., Kalnak, N., Schwinn, M., Banasik, K., Dinh, K. M., Erikstrup, C., Pedersen, O. B., Burgdorf, K. S., Ullum, H., Ostrowski, S. R., Hansen, T. F., Werge, T., & DBDS Genomic Consortium (2023). Developmental language disorder – a comprehensive study of more than 46,000 individuals. Psychiatry Research, 323, [115171]. https://doi.org/10.1016/j.psychres.2023.115171

Vancouver

Nudel R, Christensen RV, Kalnak N, Schwinn M, Banasik K, Dinh KM o.a. Developmental language disorder – a comprehensive study of more than 46,000 individuals. Psychiatry Research. 2023;323. 115171. https://doi.org/10.1016/j.psychres.2023.115171

Author

Nudel, Ron ; Christensen, Rikke Vang ; Kalnak, Nelli ; Schwinn, Michael ; Banasik, Karina ; Dinh, Khoa Manh ; Erikstrup, Christian ; Pedersen, Ole Birger ; Burgdorf, Kristoffer Sølvsten ; Ullum, Henrik ; Ostrowski, Sisse Rye ; Hansen, Thomas Folkmann ; Werge, Thomas ; DBDS Genomic Consortium. / Developmental language disorder – a comprehensive study of more than 46,000 individuals. I: Psychiatry Research. 2023 ; Bind 323.

Bibtex

@article{eedb103c321144db821373195cb905ef,
title = "Developmental language disorder – a comprehensive study of more than 46,000 individuals",
abstract = "Developmental language disorder (DLD) is characterized by enduring low language abilities with a significant functional impact, in the absence of biomedical conditions in which language impairment is part of a complex of impairments. There is a lack of awareness of DLD even among healthcare professionals. Here we estimated the prevalence of DLD and its links to reading and learning difficulties and physical and mental health in the Danish Blood Donor Study (N = 46,547), where DLD-related information is based on questionnaires (self-report). We compared the questionnaire-derived DLD status with the relevant language-related diagnoses from hospital registers. We also investigated the genetic architecture of DLD in a subset of the cohort (N = 18,380). DLD was significantly associated with reading and learning difficulties and poorer mental and physical health. DLD prevalence was 3.36%–3.70% based on questionnaires, compared with 0.04% in hospital registers. Our genetic analyses identified one genome-wide significant locus, but not a significant heritability estimate. Our study shows that DLD has health-related implications that may last into adulthood, and that DLD may be undiagnosed in general healthcare. Furthermore, DLD is likely more genetically heterogeneous than narrower developmental language phenotypes. Our results emphasize the need to raise awareness of DLD and consider criteria for molecular studies of DLD to reduce case heterogeneity.",
keywords = "Developmental language disorder, Genome-wide association study, Heritability, Specific language impairment",
author = "Ron Nudel and Christensen, {Rikke Vang} and Nelli Kalnak and Michael Schwinn and Karina Banasik and Dinh, {Khoa Manh} and Christian Erikstrup and Pedersen, {Ole Birger} and Burgdorf, {Kristoffer S{\o}lvsten} and Henrik Ullum and Ostrowski, {Sisse Rye} and Hansen, {Thomas Folkmann} and Thomas Werge and {DBDS Genomic Consortium}",
note = "Publisher Copyright: {\textcopyright} 2023",
year = "2023",
doi = "10.1016/j.psychres.2023.115171",
language = "English",
volume = "323",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Developmental language disorder – a comprehensive study of more than 46,000 individuals

AU - Nudel, Ron

AU - Christensen, Rikke Vang

AU - Kalnak, Nelli

AU - Schwinn, Michael

AU - Banasik, Karina

AU - Dinh, Khoa Manh

AU - Erikstrup, Christian

AU - Pedersen, Ole Birger

AU - Burgdorf, Kristoffer Sølvsten

AU - Ullum, Henrik

AU - Ostrowski, Sisse Rye

AU - Hansen, Thomas Folkmann

AU - Werge, Thomas

AU - DBDS Genomic Consortium

N1 - Publisher Copyright: © 2023

PY - 2023

Y1 - 2023

N2 - Developmental language disorder (DLD) is characterized by enduring low language abilities with a significant functional impact, in the absence of biomedical conditions in which language impairment is part of a complex of impairments. There is a lack of awareness of DLD even among healthcare professionals. Here we estimated the prevalence of DLD and its links to reading and learning difficulties and physical and mental health in the Danish Blood Donor Study (N = 46,547), where DLD-related information is based on questionnaires (self-report). We compared the questionnaire-derived DLD status with the relevant language-related diagnoses from hospital registers. We also investigated the genetic architecture of DLD in a subset of the cohort (N = 18,380). DLD was significantly associated with reading and learning difficulties and poorer mental and physical health. DLD prevalence was 3.36%–3.70% based on questionnaires, compared with 0.04% in hospital registers. Our genetic analyses identified one genome-wide significant locus, but not a significant heritability estimate. Our study shows that DLD has health-related implications that may last into adulthood, and that DLD may be undiagnosed in general healthcare. Furthermore, DLD is likely more genetically heterogeneous than narrower developmental language phenotypes. Our results emphasize the need to raise awareness of DLD and consider criteria for molecular studies of DLD to reduce case heterogeneity.

AB - Developmental language disorder (DLD) is characterized by enduring low language abilities with a significant functional impact, in the absence of biomedical conditions in which language impairment is part of a complex of impairments. There is a lack of awareness of DLD even among healthcare professionals. Here we estimated the prevalence of DLD and its links to reading and learning difficulties and physical and mental health in the Danish Blood Donor Study (N = 46,547), where DLD-related information is based on questionnaires (self-report). We compared the questionnaire-derived DLD status with the relevant language-related diagnoses from hospital registers. We also investigated the genetic architecture of DLD in a subset of the cohort (N = 18,380). DLD was significantly associated with reading and learning difficulties and poorer mental and physical health. DLD prevalence was 3.36%–3.70% based on questionnaires, compared with 0.04% in hospital registers. Our genetic analyses identified one genome-wide significant locus, but not a significant heritability estimate. Our study shows that DLD has health-related implications that may last into adulthood, and that DLD may be undiagnosed in general healthcare. Furthermore, DLD is likely more genetically heterogeneous than narrower developmental language phenotypes. Our results emphasize the need to raise awareness of DLD and consider criteria for molecular studies of DLD to reduce case heterogeneity.

KW - Developmental language disorder

KW - Genome-wide association study

KW - Heritability

KW - Specific language impairment

U2 - 10.1016/j.psychres.2023.115171

DO - 10.1016/j.psychres.2023.115171

M3 - Journal article

C2 - 36963307

AN - SCOPUS:85150807356

VL - 323

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

M1 - 115171

ER -

ID: 344447906