Library of biphenyl privileged substructures using a safety-catch linker approach

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Standard

Library of biphenyl privileged substructures using a safety-catch linker approach. / Severinsen, Rune; Bourne, Gregory T; Tran, Tran T; Ankersen, Michael; Begtrup, Mikael; Smythe, Mark L.

I: Journal of Combinatorial Chemistry, Bind 10, Nr. 4, 2008, s. 557-566.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Severinsen, R, Bourne, GT, Tran, TT, Ankersen, M, Begtrup, M & Smythe, ML 2008, 'Library of biphenyl privileged substructures using a safety-catch linker approach', Journal of Combinatorial Chemistry, bind 10, nr. 4, s. 557-566. https://doi.org/10.1021/cc800006g

APA

Severinsen, R., Bourne, G. T., Tran, T. T., Ankersen, M., Begtrup, M., & Smythe, M. L. (2008). Library of biphenyl privileged substructures using a safety-catch linker approach. Journal of Combinatorial Chemistry, 10(4), 557-566. https://doi.org/10.1021/cc800006g

Vancouver

Severinsen R, Bourne GT, Tran TT, Ankersen M, Begtrup M, Smythe ML. Library of biphenyl privileged substructures using a safety-catch linker approach. Journal of Combinatorial Chemistry. 2008;10(4):557-566. https://doi.org/10.1021/cc800006g

Author

Severinsen, Rune ; Bourne, Gregory T ; Tran, Tran T ; Ankersen, Michael ; Begtrup, Mikael ; Smythe, Mark L. / Library of biphenyl privileged substructures using a safety-catch linker approach. I: Journal of Combinatorial Chemistry. 2008 ; Bind 10, Nr. 4. s. 557-566.

Bibtex

@article{bc7a34c0f1d011ddbf70000ea68e967b,
title = "Library of biphenyl privileged substructures using a safety-catch linker approach",
abstract = "A biphenyl privileged structure library containing three attachment points were synthesized using a catechol-based safety-catch linker strategy. The method requires the attachment of a bromo-acid to the linker, followed by a Pd-catalyzed Suzuki cross-coupling reaction. Further derivatization, activation of the linker with strong acid and aminolysis afforded the respective products in high purity and good overall yield. To show the versatility of the synthesis, a 199-member library was generated. The library samples both conformational and chemical diversity about a well-known privileged substructure.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Rune Severinsen and Bourne, {Gregory T} and Tran, {Tran T} and Michael Ankersen and Mikael Begtrup and Smythe, {Mark L}",
note = "Keywords: Biphenyl Compounds; Catalysis; Combinatorial Chemistry Techniques; Cross-Linking Reagents; Molecular Structure",
year = "2008",
doi = "10.1021/cc800006g",
language = "English",
volume = "10",
pages = "557--566",
journal = "ACS Combinatorial Science",
issn = "2156-8952",
publisher = "ACS Publications",
number = "4",

}

RIS

TY - JOUR

T1 - Library of biphenyl privileged substructures using a safety-catch linker approach

AU - Severinsen, Rune

AU - Bourne, Gregory T

AU - Tran, Tran T

AU - Ankersen, Michael

AU - Begtrup, Mikael

AU - Smythe, Mark L

N1 - Keywords: Biphenyl Compounds; Catalysis; Combinatorial Chemistry Techniques; Cross-Linking Reagents; Molecular Structure

PY - 2008

Y1 - 2008

N2 - A biphenyl privileged structure library containing three attachment points were synthesized using a catechol-based safety-catch linker strategy. The method requires the attachment of a bromo-acid to the linker, followed by a Pd-catalyzed Suzuki cross-coupling reaction. Further derivatization, activation of the linker with strong acid and aminolysis afforded the respective products in high purity and good overall yield. To show the versatility of the synthesis, a 199-member library was generated. The library samples both conformational and chemical diversity about a well-known privileged substructure.

AB - A biphenyl privileged structure library containing three attachment points were synthesized using a catechol-based safety-catch linker strategy. The method requires the attachment of a bromo-acid to the linker, followed by a Pd-catalyzed Suzuki cross-coupling reaction. Further derivatization, activation of the linker with strong acid and aminolysis afforded the respective products in high purity and good overall yield. To show the versatility of the synthesis, a 199-member library was generated. The library samples both conformational and chemical diversity about a well-known privileged substructure.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1021/cc800006g

DO - 10.1021/cc800006g

M3 - Journal article

C2 - 18462009

VL - 10

SP - 557

EP - 566

JO - ACS Combinatorial Science

JF - ACS Combinatorial Science

SN - 2156-8952

IS - 4

ER -

ID: 10113426