The article puts forward an aesthetic and psychoanalytic analysis of Titian’s painting The Flaying of Marsyas, arguing that the painting is a reflection on the human subject as a being constituted by skin and by a core of non-humanity. The analysis is partly an answer to Melanie Harts’s article “Visualizing the Mind: Looking at Titians’ Flaying of Marsyas” (British Journal of Psychotherapy 23, 2007), addressing features of the painting uncommented by Hart, and supplementing Hart’s (Kleinian) theoretical frame by involving Didier Anzieu’s “skin ego”, Slavoj Zizek’s concept of the “non-human”, Giorgio Agamben’s term of the “Muselmann”, and Anton Ehrenzweig’s psychoanalytic theory of artistic creation. Whereas Hart is focusing on form and colour, I also turn my attention towards the texture of the painting.