Effect of endurance versus resistance training on local muscle and systemic inflammation and oxidative stress in COPD
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Effect of endurance versus resistance training on local muscle and systemic inflammation and oxidative stress in COPD. / Ryrsø, Camilla Koch; Thaning, Pia; Siebenmann, Christoph; Lundby, Carsten; Lange, Peter; Pedersen, Bente Klarlund; Hellsten, Ylva; Iepsen, Ulrik Winning.
In: Scandinavian Journal of Medicine & Science in Sports, Vol. 28, No. 11, 2018, p. 2339-2348.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of endurance versus resistance training on local muscle and systemic inflammation and oxidative stress in COPD
AU - Ryrsø, Camilla Koch
AU - Thaning, Pia
AU - Siebenmann, Christoph
AU - Lundby, Carsten
AU - Lange, Peter
AU - Pedersen, Bente Klarlund
AU - Hellsten, Ylva
AU - Iepsen, Ulrik Winning
N1 - CURIS 2018 NEXS 208
PY - 2018
Y1 - 2018
N2 - Limb muscle dysfunction in patients with COPD may be associated with local muscle and/or systemic inflammation, and therefore, we investigated whether exercise training altered markers of inflammation and oxidative stress. We obtained vastus lateralis muscle biopsies and venous blood samples from patients with COPD (n=30) before and after 8 weeks of resistance training (RT) (n=15) or endurance training (ET) (n=15). Healthy age-matched subjects were included as baseline controls (n=8). Inflammatory markers in muscle and systemically were determined by interleukins (IL), tumour necrosis factor alfa (TNF-α), leukocyte concentration together with immunohistochemical staining for macrophages. Muscle oxidative stress and antioxidant capacity were determined by NADPH oxidase (NOX) and superoxide dismutase 2 (SOD2), respectively. Before exercise training, COPD patients had a higher muscular NOX protein content and circulating IL-8, IL-18, CRP and leukocyte levels but a similar number of muscle-infiltrating macrophages compared with controls. Eight weeks of ET or RT increased muscle SOD2 content with no difference between groups. Plasma TNF-∝, increased (P < 0.05) after ET and tended to (P = 0.06) increase after RT, but had no effect on muscular NOX protein content, number of muscle-infiltrating macrophages or systemic levels of other pro-inflammatory cytokines or leukocytes. In patients with COPD, we found no evidence for muscular inflammation and no effect of exercise training. However, systemic inflammation was elevated in COPD and both training modalities induced an upregulation of muscle antioxidant capacity. This article is protected by copyright. All rights reserved.
AB - Limb muscle dysfunction in patients with COPD may be associated with local muscle and/or systemic inflammation, and therefore, we investigated whether exercise training altered markers of inflammation and oxidative stress. We obtained vastus lateralis muscle biopsies and venous blood samples from patients with COPD (n=30) before and after 8 weeks of resistance training (RT) (n=15) or endurance training (ET) (n=15). Healthy age-matched subjects were included as baseline controls (n=8). Inflammatory markers in muscle and systemically were determined by interleukins (IL), tumour necrosis factor alfa (TNF-α), leukocyte concentration together with immunohistochemical staining for macrophages. Muscle oxidative stress and antioxidant capacity were determined by NADPH oxidase (NOX) and superoxide dismutase 2 (SOD2), respectively. Before exercise training, COPD patients had a higher muscular NOX protein content and circulating IL-8, IL-18, CRP and leukocyte levels but a similar number of muscle-infiltrating macrophages compared with controls. Eight weeks of ET or RT increased muscle SOD2 content with no difference between groups. Plasma TNF-∝, increased (P < 0.05) after ET and tended to (P = 0.06) increase after RT, but had no effect on muscular NOX protein content, number of muscle-infiltrating macrophages or systemic levels of other pro-inflammatory cytokines or leukocytes. In patients with COPD, we found no evidence for muscular inflammation and no effect of exercise training. However, systemic inflammation was elevated in COPD and both training modalities induced an upregulation of muscle antioxidant capacity. This article is protected by copyright. All rights reserved.
KW - Faculty of Science
KW - Muscle dysfunction
KW - Inflammation
KW - Oxidative stress
KW - Rehabilitation
U2 - 10.1111/sms.13227
DO - 10.1111/sms.13227
M3 - Journal article
C2 - 29802649
VL - 28
SP - 2339
EP - 2348
JO - Scandinavian Journal of Medicine & Science in Sports
JF - Scandinavian Journal of Medicine & Science in Sports
SN - 0905-7188
IS - 11
ER -
ID: 197435898