Evolution of genes and genomes on the Drosophila phylogeny. Drosophila 12 Genomes Consortium
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Evolution of genes and genomes on the Drosophila phylogeny. Drosophila 12 Genomes Consortium. / Clark, Andrew G; Eisen, Michael B; Smith, Douglas R; Bergman, Casey M; Oliver, Brian; Markow, Therese A; Kaufman, Thomas C; Kellis, Manolis; Gelbart, William; Iyer, Venky N; Pollard, Daniel A; Sackton, Timothy B; Larracuente, Amanda M; Singh, Nadia D; Abad, Jose P; Abt, Dawn N; Adryan, Boris; Aguade, Montserrat; Akashi, Hiroshi; Anderson, Wyatt W; Aquadro, Charles F; Ardell, David H; Arguello, Roman; Artieri, Carlo G; Barbash, Daniel A; Barker, Daniel; Barsanti, Paolo; Batterham, Phil; Batzoglou, Serafim; Begun, Dave; Bhutkar, Arjun; Blanco, Enrico; Bosak, Stephanie A; Bradley, Robert K; Brand, Adrianne D; Brent, Michael R; Brooks, Angela N; Brown, Randall H; Butlin, Roger K; Caggese, Corrado; Calvi, Brian R; Bernardo de Carvalho, A; Caspi, Anat; Castrezana, Sergio; Celniker, Susan E; Chang, Jean L; Garcia, Ana C L; Nielsen, Rasmus; Pedersen, Jakob Skou; Garrett Vieira, Filipe Jorge; Drosophila 12 Genomes Consortium.
In: Nature, Vol. 450, No. 7167, 2007, p. 203-18.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Evolution of genes and genomes on the Drosophila phylogeny.
T2 - Drosophila 12 Genomes Consortium
AU - Clark, Andrew G
AU - Eisen, Michael B
AU - Smith, Douglas R
AU - Bergman, Casey M
AU - Oliver, Brian
AU - Markow, Therese A
AU - Kaufman, Thomas C
AU - Kellis, Manolis
AU - Gelbart, William
AU - Iyer, Venky N
AU - Pollard, Daniel A
AU - Sackton, Timothy B
AU - Larracuente, Amanda M
AU - Singh, Nadia D
AU - Abad, Jose P
AU - Abt, Dawn N
AU - Adryan, Boris
AU - Aguade, Montserrat
AU - Akashi, Hiroshi
AU - Anderson, Wyatt W
AU - Aquadro, Charles F
AU - Ardell, David H
AU - Arguello, Roman
AU - Artieri, Carlo G
AU - Barbash, Daniel A
AU - Barker, Daniel
AU - Barsanti, Paolo
AU - Batterham, Phil
AU - Batzoglou, Serafim
AU - Begun, Dave
AU - Bhutkar, Arjun
AU - Blanco, Enrico
AU - Bosak, Stephanie A
AU - Bradley, Robert K
AU - Brand, Adrianne D
AU - Brent, Michael R
AU - Brooks, Angela N
AU - Brown, Randall H
AU - Butlin, Roger K
AU - Caggese, Corrado
AU - Calvi, Brian R
AU - Bernardo de Carvalho, A
AU - Caspi, Anat
AU - Castrezana, Sergio
AU - Celniker, Susan E
AU - Chang, Jean L
AU - Garcia, Ana C L
AU - Nielsen, Rasmus
AU - Pedersen, Jakob Skou
AU - Garrett Vieira, Filipe Jorge
AU - Drosophila 12 Genomes Consortium
PY - 2007
Y1 - 2007
N2 - Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
AB - Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
KW - Faculty of Science
KW - Animals
KW - Codon
KW - DNA
KW - DNA Transposable Elements
KW - Drosophila
KW - Drosophila Proteins
KW - Evolution, Molecular
KW - Molecular
KW - Gene Order
KW - Genes, Insect
KW - Genome, Insect
KW - Genome, Mitochondrial
KW - Genomics
KW - Immunity
KW - Multigene Family
KW - Phylogeny
KW - RNA, Untranslated
KW - Reproduction
KW - Sequence Alignment
KW - Analysis, DNA
KW - Synteny
U2 - 10.1038/nature06341
DO - 10.1038/nature06341
M3 - Journal article
C2 - 17994087
VL - 450
SP - 203
EP - 218
JO - Nature
JF - Nature
SN - 0028-0836
IS - 7167
ER -
ID: 4960404