Excessive weight gain followed by catch-down in exclusively breastfed infants: An exploratory study
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Excessive weight gain followed by catch-down in exclusively breastfed infants : An exploratory study. / Larsson, Melanie Wange; Lind, Mads Vendelbo; Larnkjær, Anni; Due, Anette P; Blom, Irina C; Wells, Jonathan; Lai, Ching T; Mølgaard, Christian; Geddes, Donna T; Michaelsen, Kim F.
In: Nutrients, Vol. 10, No. 9, 1290, 12.09.2018.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Excessive weight gain followed by catch-down in exclusively breastfed infants
T2 - An exploratory study
AU - Larsson, Melanie Wange
AU - Lind, Mads Vendelbo
AU - Larnkjær, Anni
AU - Due, Anette P
AU - Blom, Irina C
AU - Wells, Jonathan
AU - Lai, Ching T
AU - Mølgaard, Christian
AU - Geddes, Donna T
AU - Michaelsen, Kim F.
N1 - CURIS 2018 NEXS 321
PY - 2018/9/12
Y1 - 2018/9/12
N2 - Some infants experience excessive weight gain (EWG) during exclusive breastfeeding, but causes and consequences are unknown. The objective was to identify factors associated with early EWG. Infants with EWG (HW-group) were examined at 5, 9 and 18 mo and compared to a breastfed group with normal weight gain (NW-group). Anthropometry, body composition, milk and blood samples, and milk intake were measured. Mean body-mass-index-for-age z-scores (BAZ) increased 1.93 from birth to 5 mo in the HW-group (n = 13) while the NW-group (n = 17) was unchanged (-0.01). The HW-group had 70% more fat mass at 5 mo, and then showed marked catch-down in BAZ from 5 to 18 mo (-0.84). Milk intake at 5⁻6 mo did not differ between the groups. In the HW-group milk-leptin was lower at 5 mo and serum-leptin was considerably higher at 5 and 9 mo compared to the NW-group. Serum-leptin at 5 mo was positively associated with weight-for-age z-score (WAZ) and fat mass and negatively with WAZ change from 5 to 9 mo. In conclusion, breastfed infants with EWG had catch-down growth when other foods were introduced. Low milk-leptin in the HW-group may have stimulated appetite and milk intake when weight gain was high. High serum-leptin in the HW-group suggests early leptin resistance, which could impact cerebral regulation of energy intake. Larger studies are needed to confirm these results.
AB - Some infants experience excessive weight gain (EWG) during exclusive breastfeeding, but causes and consequences are unknown. The objective was to identify factors associated with early EWG. Infants with EWG (HW-group) were examined at 5, 9 and 18 mo and compared to a breastfed group with normal weight gain (NW-group). Anthropometry, body composition, milk and blood samples, and milk intake were measured. Mean body-mass-index-for-age z-scores (BAZ) increased 1.93 from birth to 5 mo in the HW-group (n = 13) while the NW-group (n = 17) was unchanged (-0.01). The HW-group had 70% more fat mass at 5 mo, and then showed marked catch-down in BAZ from 5 to 18 mo (-0.84). Milk intake at 5⁻6 mo did not differ between the groups. In the HW-group milk-leptin was lower at 5 mo and serum-leptin was considerably higher at 5 and 9 mo compared to the NW-group. Serum-leptin at 5 mo was positively associated with weight-for-age z-score (WAZ) and fat mass and negatively with WAZ change from 5 to 9 mo. In conclusion, breastfed infants with EWG had catch-down growth when other foods were introduced. Low milk-leptin in the HW-group may have stimulated appetite and milk intake when weight gain was high. High serum-leptin in the HW-group suggests early leptin resistance, which could impact cerebral regulation of energy intake. Larger studies are needed to confirm these results.
KW - Faculty of Science
KW - Exclusively breastfed infants
KW - Weight-gain
KW - Infant growth
KW - Body composition
KW - Human milk composition
KW - Leptin
KW - Human milk intake
KW - Pediatrics
KW - Breastfeeding
U2 - 10.3390/nu10091290
DO - 10.3390/nu10091290
M3 - Journal article
C2 - 30213080
VL - 10
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 9
M1 - 1290
ER -
ID: 202510452