Fish oil as a potential activator of brown and beige fat thermogenesis
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Fish oil as a potential activator of brown and beige fat thermogenesis. / Lund, Jens; Larsen, Lesli Hingstrup; Lauritzen, Lotte.
In: Adipocytes, Vol. 7, No. 2, 2018, p. 88-95.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Fish oil as a potential activator of brown and beige fat thermogenesis
AU - Lund, Jens
AU - Larsen, Lesli Hingstrup
AU - Lauritzen, Lotte
N1 - CURIS 2018 NEXS 095
PY - 2018
Y1 - 2018
N2 - Numerous studies have shown that feeding rodents n-3 polyunsaturated fatty acids attenuates adiposity. Moreover, meta-analyses of human dietary intervention studies indicate that fish oil (eicosapentaenoic and docosahexaenoic acid) supplementation might reduce waist circumference. A recent line of research suggests that browning of white adipose depots and activation of uncoupled respiration in brown fat contributes to these effects. This mini-review summarizes the observations in rodents, highlights several mechanisms that might explain these observations and discusses the translational potential. Given the available in vivo evidence and the ability of human adipocytes to aquire a beige phenotype in response to eicosapentaenoic acid incubation, future studies should test the hypothesis that fish oil activates thermogenic brown and beige adipose tissue in humans.
AB - Numerous studies have shown that feeding rodents n-3 polyunsaturated fatty acids attenuates adiposity. Moreover, meta-analyses of human dietary intervention studies indicate that fish oil (eicosapentaenoic and docosahexaenoic acid) supplementation might reduce waist circumference. A recent line of research suggests that browning of white adipose depots and activation of uncoupled respiration in brown fat contributes to these effects. This mini-review summarizes the observations in rodents, highlights several mechanisms that might explain these observations and discusses the translational potential. Given the available in vivo evidence and the ability of human adipocytes to aquire a beige phenotype in response to eicosapentaenoic acid incubation, future studies should test the hypothesis that fish oil activates thermogenic brown and beige adipose tissue in humans.
KW - Faculty of Science
KW - Fish oil
KW - Eicosapentaenoic acid (EPA)
KW - Brown adipose tissue
KW - Browning
KW - Beige adipocytes
KW - UCP1
KW - Non-shivering thermogenesis
KW - GPR120
KW - TRPV1
KW - miR-30b
U2 - 10.1080/21623945.2018.1442980
DO - 10.1080/21623945.2018.1442980
M3 - Review
C2 - 29521565
VL - 7
SP - 88
EP - 95
JO - Adipocytes
JF - Adipocytes
SN - 1550-2082
IS - 2
ER -
ID: 192515870