Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation
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- Teumer et al_Nature Communications_2018_Vol 9_4455
Final published version, 1.81 MB, PDF document
Thyroid dysfunction is an important public health problem, which affects 10% of the general population and increases the risk of cardiovascular morbidity and mortality. Many aspects of thyroid hormone regulation have only partly been elucidated, including its transport, metabolism, and genetic determinants. Here we report a large meta-analysis of genome-wide association studies for thyroid function and dysfunction, testing 8 million genetic variants in up to 72,167 individuals. One-hundred-and-nine independent genetic variants are associated
with these traits. A genetic risk score, calculated to assess their combined effects on clinical end points, shows significant associations with increased risk of both overt (Graves’ disease) and subclinical thyroid disease, as well as clinical complications. By functional follow-up on selected signals, we identify a novel thyroid hormone transporter (SLC17A4) and a metabolizing enzyme (AADAT). Together, these results provide new knowledge about thyroid hormone physiology and disease, opening new possibilities for therapeutic targets.
with these traits. A genetic risk score, calculated to assess their combined effects on clinical end points, shows significant associations with increased risk of both overt (Graves’ disease) and subclinical thyroid disease, as well as clinical complications. By functional follow-up on selected signals, we identify a novel thyroid hormone transporter (SLC17A4) and a metabolizing enzyme (AADAT). Together, these results provide new knowledge about thyroid hormone physiology and disease, opening new possibilities for therapeutic targets.
Original language | English |
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Article number | 4455 |
Journal | Nature Communications |
Volume | 9 |
Number of pages | 14 |
ISSN | 2041-1723 |
DOIs | |
Publication status | Published - 2018 |
- Faculty of Science - Thyroid dysfunction, Thyroid hormone regulation, Genome-wide analysis, Genetic variants, Thyroid hormone transporter (SLC17A4), Metabolyzing hormone (AADAT)
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