Early life DNA vaccination with the H gene of Canine distemper virus induces robust protection against distemper

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  • Trine Hammer Jensen
  • Line Nielsen
  • Aasted, Bent
  • Merete Blixenkrone-Møller

Young mink kits (n = 8)were vaccinated withDNA plasmids encoding the viral haemagglutinin protein (H) of a vaccine strain of Canine distemper virus (CDV). Virus neutralising (VN) antibodieswere induced after 2 immunisations and after the third immunisation all kits had high VN antibody titres. The VN antibody titres remained high for more than 4 months and the mink were protected against viraemia, lymphopenia, clinical disease and changes in the percentage of IFN- producing peripheral blood leucocytes after challenge inoculation with a recent wild type strain of CDV. Essentially, these results demonstrate that early life DNA vaccination with the H gene of a CDV vaccine strain induced robust protective immunity against a recent wild type CDV.

Udgave nummer38
Sider (fra-til)5178–5183
Antal sider6
StatusUdgivet - 2009

ID: 13458253