Characterization of upper thoracic spinal neurons receiving noxious cardiac and/or somatic inputs in diabetic rats
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The aim of the present study was to examine spinal processing of cardiac and somatic nociceptive input in rats with STZ-induced diabetes. Type 1 diabetes was induced with streptozotocin (50mg/kg) in 14 male Sprague-Dawley rats and citrate buffer was injected in 14 control rats. After 4-11weeks, the rats were anesthetized with pentobarbital, ventilated and paralyzed. A laminectomy enabled extracellular recording of T(3) spinal cord neuronal activity. Intrapericardial administration of a mixture of algogenic chemicals (bradykinin, serotonin, prostaglandin E(2) (all at 10(-5)M), and adenosine (10(-3)M)) was applied to activate nociceptors of cardiac afferent nerve endings. Furthermore, somatic receptive properties were examined by applying innocuous (brush and light pressure) and noxious (pinch) cutaneous mechanical stimuli. Diabetes-induced increases in spontaneous activity were observed in subsets of neurons exhibiting long-lasting excitatory responses to administration of the algogenic mixture. Algogenic chemicals altered activity of a larger proportion of neurons from diabetic animals (73/111) than control animals (55/115, P
Originalsprog | Engelsk |
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Tidsskrift | Autonomic Neuroscience: Basic and Clinical |
Vol/bind | 165 |
Udgave nummer | 2 |
Sider (fra-til) | 168-177 |
ISSN | 1566-0702 |
DOI | |
Status | Udgivet - 7 dec. 2011 |
- Det tidligere Farmaceutiske Fakultet
Forskningsområder
ID: 33968861