VEGF-dependent mechanism of anti-angiogenic action of diamond nanoparticles in Glioblastoma Multiforme tumor
Publikation: Bidrag til bog/antologi/rapport › Konferencebidrag i proceedings › Forskning › fagfællebedømt
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VEGF-dependent mechanism of anti-angiogenic action of diamond nanoparticles in Glioblastoma Multiforme tumor. / Grodzik, M.; Sawosz, E.; Wierzbicki, M.; Hotowy, Anna Malgorzata; Prasek, M.; Jaworski, J.; Chwalibog, André.
Nanotechnology 2012: Bio Sensors, Instruments, Medical, Environment and Energy. Bind 3 NSTI Nano Science and Technology Institute, 2012. s. 218-221.Publikation: Bidrag til bog/antologi/rapport › Konferencebidrag i proceedings › Forskning › fagfællebedømt
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TY - GEN
T1 - VEGF-dependent mechanism of anti-angiogenic action of diamond nanoparticles in Glioblastoma Multiforme tumor
AU - Grodzik, M.
AU - Sawosz, E.
AU - Wierzbicki, M.
AU - Hotowy, Anna Malgorzata
AU - Prasek, M.
AU - Jaworski, J.
AU - Chwalibog, André
PY - 2012
Y1 - 2012
N2 - Malignant gliomas are highly lethal cancers dependent on angiogenesis. The concept of treating tumors by inhibiting tumor angiogenesis was first articulated almost 30 years ago. Inhibition of tumor angiogenesis suppresses both tumor growth and metastasis. We determined the inhibition effect of diamond nanoparticles on the growth of brain tumor (cultured on CAM membrane) and the development of its blood vessels. We hypothesize that diamond nanoparticles can bind VEGF or their receptors and this way influence of signal transduction between cells. The aim of our study was to evaluate the influence of diamond nanoparticle on VEGF level and inhibition of the brain tumor angiogenesis. We evaluated interaction of VEGF-A and VEGF-receptor proteins with diamond nanoparticles (TEM), visualized lower the permeability of blood vessels after diamond nanoparticles treatment and determined localization in the cell and expression on protein level VEGF-A and VEGF-A-receptor.
AB - Malignant gliomas are highly lethal cancers dependent on angiogenesis. The concept of treating tumors by inhibiting tumor angiogenesis was first articulated almost 30 years ago. Inhibition of tumor angiogenesis suppresses both tumor growth and metastasis. We determined the inhibition effect of diamond nanoparticles on the growth of brain tumor (cultured on CAM membrane) and the development of its blood vessels. We hypothesize that diamond nanoparticles can bind VEGF or their receptors and this way influence of signal transduction between cells. The aim of our study was to evaluate the influence of diamond nanoparticle on VEGF level and inhibition of the brain tumor angiogenesis. We evaluated interaction of VEGF-A and VEGF-receptor proteins with diamond nanoparticles (TEM), visualized lower the permeability of blood vessels after diamond nanoparticles treatment and determined localization in the cell and expression on protein level VEGF-A and VEGF-A-receptor.
KW - Former LIFE faculty
KW - angiogenesis
KW - cancer
KW - diamond
KW - glioma
KW - nanoparticle
KW - VEGF
M3 - Article in proceedings
SN - 978-.1-4665-6276-9
VL - 3
SP - 218
EP - 221
BT - Nanotechnology 2012: Bio Sensors, Instruments, Medical, Environment and Energy
PB - NSTI Nano Science and Technology Institute
ER -
ID: 44560673