Herring and chicken/pork meals lead to differences in plasma levels of TCA intermediates and arginine metabolites in overweight and obese men and women
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Herring and chicken/pork meals lead to differences in plasma levels of TCA intermediates and arginine metabolites in overweight and obese men and women. / Vincent, Andrew; Savolainen, Otto I; Sen, Partho; Carlsson, Nils-Gunnar; Almgren, Annette; Lindqvist, Helen; Lind, Mads Vendelbo; Undeland, Ingrid; Sandberg, Ann-Sofie; Ross, Alastair B.
I: Molecular Nutrition & Food Research, Bind 61, Nr. 3, 1600400, 2017.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Herring and chicken/pork meals lead to differences in plasma levels of TCA intermediates and arginine metabolites in overweight and obese men and women
AU - Vincent, Andrew
AU - Savolainen, Otto I
AU - Sen, Partho
AU - Carlsson, Nils-Gunnar
AU - Almgren, Annette
AU - Lindqvist, Helen
AU - Lind, Mads Vendelbo
AU - Undeland, Ingrid
AU - Sandberg, Ann-Sofie
AU - Ross, Alastair B.
N1 - CURIS 2017 NEXS 029
PY - 2017
Y1 - 2017
N2 - Scope: What effect does replacing chicken or pork with herring as the main dietary source of protein have on the human plasma metabolome?Method and results: A randomised crossover trial with 15 healthy obese men and women (age 24–70 years). Subjects were randomly assigned to four weeks of herring diet or a reference diet of chicken and lean pork, five meals per week, followed by a washout and the other intervention arm. Fasting blood serum metabolites were analysed at 0, 2 and 4 weeks for eleven subjects with available samples, using GC-MS based metabolomics.The herring diet decreased plasma citrate, fumarate, isocitrate, glycolate, oxalate, agmatine and methyhistidine and increased asparagine, ornithine, glutamine and the hexosamine glucosamine. Modelling found that the tricarboxylic acid cycle, glyoxylate, and argininemetabolism were affected by the intervention. The effect on arginine metabolism was supported by an increasein blood nitric oxide in males on the herring diet.Conclusion: The results suggest that eating herring instead of chicken and lean pork leads to important metabolic effects, particularly on energy and amino acid metabolism. Our findings support the hypothesis that there are metabolic effects of herring intake unrelated to the long chain n-3 polyunsaturated fatty acid content.
AB - Scope: What effect does replacing chicken or pork with herring as the main dietary source of protein have on the human plasma metabolome?Method and results: A randomised crossover trial with 15 healthy obese men and women (age 24–70 years). Subjects were randomly assigned to four weeks of herring diet or a reference diet of chicken and lean pork, five meals per week, followed by a washout and the other intervention arm. Fasting blood serum metabolites were analysed at 0, 2 and 4 weeks for eleven subjects with available samples, using GC-MS based metabolomics.The herring diet decreased plasma citrate, fumarate, isocitrate, glycolate, oxalate, agmatine and methyhistidine and increased asparagine, ornithine, glutamine and the hexosamine glucosamine. Modelling found that the tricarboxylic acid cycle, glyoxylate, and argininemetabolism were affected by the intervention. The effect on arginine metabolism was supported by an increasein blood nitric oxide in males on the herring diet.Conclusion: The results suggest that eating herring instead of chicken and lean pork leads to important metabolic effects, particularly on energy and amino acid metabolism. Our findings support the hypothesis that there are metabolic effects of herring intake unrelated to the long chain n-3 polyunsaturated fatty acid content.
KW - Faculty of Science
KW - Arginine
KW - Central energy metabolism
KW - Chicken
KW - Herring
KW - Pork
U2 - 10.1002/mnfr.201600400
DO - 10.1002/mnfr.201600400
M3 - Journal article
C2 - 27801550
VL - 61
JO - Molecular Nutrition & Food Research
JF - Molecular Nutrition & Food Research
SN - 1613-4125
IS - 3
M1 - 1600400
ER -
ID: 172062455