New perspectives on the development of muscle contractures following central motor lesions
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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New perspectives on the development of muscle contractures following central motor lesions. / Pingel, Jessica; Bartels, Else Marie; Nielsen, Jens Bo.
I: Journal of Physiology, Bind 595, Nr. 4, 2017, s. 1027-1038.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - New perspectives on the development of muscle contractures following central motor lesions
AU - Pingel, Jessica
AU - Bartels, Else Marie
AU - Nielsen, Jens Bo
N1 - CURIS 2017 NEXS 055
PY - 2017
Y1 - 2017
N2 - Muscle contractures are common in patients with central motor lesions, but the mechanisms responsible for the development of contractures are still unclear. Increased or decreased neural activation, protracted placement of a joint with the muscle in a short position and muscle atrophy have been suggested to be involved, but none of these mechanisms are sufficient to explain the development of muscle contractures alone. Here we propose that changes in tissue homeostasis in the neuro-muscular-tendon-connective tissue complex is at the heart of the development of contractures, and that an integrated physiological understanding of the interaction between neural, mechanical and metabolic factors, as well as genetic and epigenetic factors, is necessary in order to unravel the mechanisms that result in muscle contractures. We hope thereby to contribute to a reconsideration of how and why muscle contractures develop in a way which will open a window towards new insight in this area in the future. This article is protected by copyright. All rights reserved.
AB - Muscle contractures are common in patients with central motor lesions, but the mechanisms responsible for the development of contractures are still unclear. Increased or decreased neural activation, protracted placement of a joint with the muscle in a short position and muscle atrophy have been suggested to be involved, but none of these mechanisms are sufficient to explain the development of muscle contractures alone. Here we propose that changes in tissue homeostasis in the neuro-muscular-tendon-connective tissue complex is at the heart of the development of contractures, and that an integrated physiological understanding of the interaction between neural, mechanical and metabolic factors, as well as genetic and epigenetic factors, is necessary in order to unravel the mechanisms that result in muscle contractures. We hope thereby to contribute to a reconsideration of how and why muscle contractures develop in a way which will open a window towards new insight in this area in the future. This article is protected by copyright. All rights reserved.
KW - Faculty of Science
KW - Muscle
KW - Contracture
KW - Central motor lesions
U2 - 10.1113/JP272767
DO - 10.1113/JP272767
M3 - Review
C2 - 27779750
VL - 595
SP - 1027
EP - 1038
JO - The Journal of Physiology
JF - The Journal of Physiology
SN - 0022-3751
IS - 4
ER -
ID: 167914996