Personalized Medicine Through GPCR Pharmacogenomics
Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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Personalized Medicine Through GPCR Pharmacogenomics. / Hauser, Alexander Sebastian.
Personalized Medicine Through GPCR Pharmacogenomics. red. / Terry Kenakin. Elsevier, 2021.Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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TY - CHAP
T1 - Personalized Medicine Through GPCR Pharmacogenomics
AU - Hauser, Alexander Sebastian
PY - 2021
Y1 - 2021
N2 - Understanding the magnitude of response to a given treatment at an individual level is one of the most important and long-standing challenges in personalized medicine and pharmacogenomics. A great deal of effort has been placed on understanding variation in drug transport and metabolism. However, little is known about how variability in receptor drug targets affects treatment regimens. G protein-coupled receptors (GPCRs) are the single most prevalent drug target family. Elucidating the spectrum and impact of how a GPCR variant influences ligand binding, signaling and, ultimately, therapeutic effect is vital and could serve as the next important step for understanding variability in drug response.
AB - Understanding the magnitude of response to a given treatment at an individual level is one of the most important and long-standing challenges in personalized medicine and pharmacogenomics. A great deal of effort has been placed on understanding variation in drug transport and metabolism. However, little is known about how variability in receptor drug targets affects treatment regimens. G protein-coupled receptors (GPCRs) are the single most prevalent drug target family. Elucidating the spectrum and impact of how a GPCR variant influences ligand binding, signaling and, ultimately, therapeutic effect is vital and could serve as the next important step for understanding variability in drug response.
KW - Faculty of Health and Medical Sciences
U2 - 10.1016/B978-0-12-820472-6.00100-6
DO - 10.1016/B978-0-12-820472-6.00100-6
M3 - Book chapter
BT - Personalized Medicine Through GPCR Pharmacogenomics
A2 - Kenakin, Terry
PB - Elsevier
ER -
ID: 279288718