One anastomosis gastric bypass in the treatment of obesity: Effects on body weight and the metabolome
Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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One anastomosis gastric bypass in the treatment of obesity : Effects on body weight and the metabolome. / Mika, Adriana; Sledzinski, Tomasz; Proczko-Stepaniak, Monika; Magkos, Faidon.
Obesity and Diabetes: Scientific Advances and Best Practice. red. / Joel Faintuch; Salomão Faintuch. 2. udg. Cham : Springer, 2020. s. 777-790 (Obesity and Diabetes).Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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TY - CHAP
T1 - One anastomosis gastric bypass in the treatment of obesity
T2 - Effects on body weight and the metabolome
AU - Mika, Adriana
AU - Sledzinski, Tomasz
AU - Proczko-Stepaniak, Monika
AU - Magkos, Faidon
N1 - CURIS 2020 NEXS 390
PY - 2020
Y1 - 2020
N2 - Bariatric surgery is the most effective treatment for obesity, producing massive and durable weight loss. One anastomosis gastric bypass (OAGB) is a restrictive and malabsorptive procedure that is rapidly gaining in popularity; it is simpler technically than other common procedures and has a low rate of complications. OAGB has similar, if not better, weight loss results than Roux-en-Y gastric bypass and biliopancreatic diversion, likely because of the exclusion of a longer biliopancreatic limb. In addition to weight loss, OAGB has been shown to improve many of the commonest metabolic abnormalities associated with obesity such as insulin resistance. Recent studies using traditional analytical techniques, however also more advanced metabolomics techniques, provide important insights into the potential mechanisms for the physiological effects of OAGB, including improved lipid profile (normalization of triacylglycerol and cholesterol levels), reduced concentrations of total free fatty acids however increased branched-chain fatty acids, decreased branched-chain amino acid levels, and increased circulating bile acids. All these changes likely contribute to improved glucose homeostasis and cardiometabolic health.
AB - Bariatric surgery is the most effective treatment for obesity, producing massive and durable weight loss. One anastomosis gastric bypass (OAGB) is a restrictive and malabsorptive procedure that is rapidly gaining in popularity; it is simpler technically than other common procedures and has a low rate of complications. OAGB has similar, if not better, weight loss results than Roux-en-Y gastric bypass and biliopancreatic diversion, likely because of the exclusion of a longer biliopancreatic limb. In addition to weight loss, OAGB has been shown to improve many of the commonest metabolic abnormalities associated with obesity such as insulin resistance. Recent studies using traditional analytical techniques, however also more advanced metabolomics techniques, provide important insights into the potential mechanisms for the physiological effects of OAGB, including improved lipid profile (normalization of triacylglycerol and cholesterol levels), reduced concentrations of total free fatty acids however increased branched-chain fatty acids, decreased branched-chain amino acid levels, and increased circulating bile acids. All these changes likely contribute to improved glucose homeostasis and cardiometabolic health.
KW - Faculty of Science
KW - Omega-loop gastric bypass
KW - Mini gastric bypass
KW - Fatty acid profile
KW - Branched chain fatty acids
KW - Branched chain amino acids
KW - Bile acids
U2 - 10.1007/978-3-030-53370-0_58
DO - 10.1007/978-3-030-53370-0_58
M3 - Book chapter
SN - 9783030533694
T3 - Obesity and Diabetes
SP - 777
EP - 790
BT - Obesity and Diabetes
A2 - Faintuch, Joel
A2 - Faintuch, Salomão
PB - Springer
CY - Cham
ER -
ID: 255730206