Prevotella abundance and salivary amylase gene copy number predict fat loss in response to wholegrain diets
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Prevotella abundance and salivary amylase gene copy number predict fat loss in response to wholegrain diets. / Christensen, Lars; Hjorth, Mads Fiil; Krych, Lukasz; Licht, Tine Rask; Lauritzen, Lotte; Magkos, Faidon; Roager, Henrik Munch.
I: Frontiers in Nutrition, Bind 9, 947349, 2022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Prevotella abundance and salivary amylase gene copy number predict fat loss in response to wholegrain diets
AU - Christensen, Lars
AU - Hjorth, Mads Fiil
AU - Krych, Lukasz
AU - Licht, Tine Rask
AU - Lauritzen, Lotte
AU - Magkos, Faidon
AU - Roager, Henrik Munch
N1 - Copyright © 2022 Christensen, Hjorth, Krych, Licht, Lauritzen, Magkos and Roager.
PY - 2022
Y1 - 2022
N2 - Background: Salivary amylase (AMY1) gene copy number (CN) and Prevotella abundance in the gut are involved in carbohydrate digestion in the upper and lower gastrointestinal tract, respectively; and have been suggested as prognostic biomarkers for weight loss among overweight individuals consuming diets rich in fiber and wholegrains.Objective: We hypothesized that Prevotella abundance would be linked to greater loss of body fat after wholegrain consumption among individuals with low AMY1 CN, but not in those with high AMY1 CN.Methods: We reanalyzed data from two independent randomized ad libitum wholegrain interventions (fiber intake ∼33 g/d for 6-8 weeks), to investigate the relationship between baseline Prevotella abundance and body fat loss among healthy, overweight participants stratified into two groups by median AMY1 CN. Individuals with no detected Prevotella spp. were excluded from the main analysis.Results: In both studies, individuals with low AMY1 CN exhibited a positive correlation between baseline Prevotella abundance and fat loss after consuming the wholegrain diet (r > 0.5, P < 0.05), but no correlation among participants with high AMY1 CN (P ≥ 0.6). Following consumption of the refined wheat control diets, there were no associations between baseline Prevotella abundance and changes in body fat in any of the AMY1 groups.Conclusion: These results suggest that Prevotella abundance together with AMY1 CN can help predict fat loss in response to ad libitum wholegrain diets, highlighting the potential of these biomarkers in personalized obesity management.
AB - Background: Salivary amylase (AMY1) gene copy number (CN) and Prevotella abundance in the gut are involved in carbohydrate digestion in the upper and lower gastrointestinal tract, respectively; and have been suggested as prognostic biomarkers for weight loss among overweight individuals consuming diets rich in fiber and wholegrains.Objective: We hypothesized that Prevotella abundance would be linked to greater loss of body fat after wholegrain consumption among individuals with low AMY1 CN, but not in those with high AMY1 CN.Methods: We reanalyzed data from two independent randomized ad libitum wholegrain interventions (fiber intake ∼33 g/d for 6-8 weeks), to investigate the relationship between baseline Prevotella abundance and body fat loss among healthy, overweight participants stratified into two groups by median AMY1 CN. Individuals with no detected Prevotella spp. were excluded from the main analysis.Results: In both studies, individuals with low AMY1 CN exhibited a positive correlation between baseline Prevotella abundance and fat loss after consuming the wholegrain diet (r > 0.5, P < 0.05), but no correlation among participants with high AMY1 CN (P ≥ 0.6). Following consumption of the refined wheat control diets, there were no associations between baseline Prevotella abundance and changes in body fat in any of the AMY1 groups.Conclusion: These results suggest that Prevotella abundance together with AMY1 CN can help predict fat loss in response to ad libitum wholegrain diets, highlighting the potential of these biomarkers in personalized obesity management.
KW - Faculty of Science
KW - Weight loss
KW - Obesity
KW - Enterotypes
KW - Microbiota
KW - Prevotella
KW - AMY1
KW - Wholegrain
KW - Dietary fiber
U2 - 10.3389/fnut.2022.947349
DO - 10.3389/fnut.2022.947349
M3 - Journal article
C2 - 36071931
VL - 9
JO - Frontiers in Nutrition
JF - Frontiers in Nutrition
SN - 2296-861X
M1 - 947349
ER -
ID: 319415709