Saturated fats and health: A reassessment and proposal for food-based recommendations: JACC State-of-the-Art Review
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Saturated fats and health: A reassessment and proposal for food-based recommendations : JACC State-of-the-Art Review. / Astrup, Arne; Magkos, Faidon; Bier, Dennis M; Brenna, J Thomas; de Oliveira Otto, Marcia C; Hill, James O; King, Janet C; Mente, Andrew; Ordovas, Jose M; Volek, Jeff S; Yusuf, Salim; Krauss, Ronald M.
I: Journal of the American College of Cardiology, Bind 76, Nr. 7, 2020, s. 844-857.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Saturated fats and health: A reassessment and proposal for food-based recommendations
T2 - JACC State-of-the-Art Review
AU - Astrup, Arne
AU - Magkos, Faidon
AU - Bier, Dennis M
AU - Brenna, J Thomas
AU - de Oliveira Otto, Marcia C
AU - Hill, James O
AU - King, Janet C
AU - Mente, Andrew
AU - Ordovas, Jose M
AU - Volek, Jeff S
AU - Yusuf, Salim
AU - Krauss, Ronald M
N1 - Copyright © 2020. Published by Elsevier Inc.
PY - 2020
Y1 - 2020
N2 - The recommendation to limit dietary saturated fatty acid (SFA) intake has persisted despite mounting evidence to the contrary. Most recent meta-analyses of randomized trials and observational studies found no beneficial effects of reducing SFA intake on cardiovascular disease (CVD) and total mortality, and instead found protective effects against stroke. Although SFAs increase low-density lipoprotein (LDL)-cholesterol, in most individuals, this is not due to increasing levels of small, dense LDL particles, but rather larger LDL which are much less strongly related to CVD risk. It is also apparent that the health effects of foods cannot be predicted by their content in any nutrient group, without considering the overall macronutrient distribution. Whole-fat dairy, unprocessed meat, eggs and dark chocolate are SFA-rich foods with a complex matrix that are not associated with increased risk of CVD. The totality of available evidence does not support further limiting the intake of such foods.
AB - The recommendation to limit dietary saturated fatty acid (SFA) intake has persisted despite mounting evidence to the contrary. Most recent meta-analyses of randomized trials and observational studies found no beneficial effects of reducing SFA intake on cardiovascular disease (CVD) and total mortality, and instead found protective effects against stroke. Although SFAs increase low-density lipoprotein (LDL)-cholesterol, in most individuals, this is not due to increasing levels of small, dense LDL particles, but rather larger LDL which are much less strongly related to CVD risk. It is also apparent that the health effects of foods cannot be predicted by their content in any nutrient group, without considering the overall macronutrient distribution. Whole-fat dairy, unprocessed meat, eggs and dark chocolate are SFA-rich foods with a complex matrix that are not associated with increased risk of CVD. The totality of available evidence does not support further limiting the intake of such foods.
KW - Faculty of Science
KW - Cardiovascular disease
KW - Diet
KW - Saturated fat
KW - Food matrix
U2 - 10.1016/j.jacc.2020.05.077
DO - 10.1016/j.jacc.2020.05.077
M3 - Review
C2 - 32562735
VL - 76
SP - 844
EP - 857
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
IS - 7
ER -
ID: 243343145