Focal and restricted traumatic injury models in the rodent brain: limitations, possibilities, and challenges
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Focal and restricted traumatic injury models in the rodent brain: limitations, possibilities, and challenges. / Mogensen, Jesper; Rytter, Hana Malá.
Animal Models of Neurotrauma. ed. / Mårten Risling; Johan Davidsson. Springer, 2019. p. 19-46 (Neuromethods; No. 149).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Focal and restricted traumatic injury models in the rodent brain: limitations, possibilities, and challenges
AU - Mogensen, Jesper
AU - Rytter, Hana Malá
PY - 2019
Y1 - 2019
N2 - Animal models of traumatic brain injury are primarily utilized for the purpose of either (a) conducting basic research—for instance regarding the neurocognitive organization of the brain or (b) the development and evaluation of therapeutic interventions—such as pharmacological and behavioral methods as well as environmental manipulations. While studies focusing on development of therapeutic methods may primarily call for the use of more “ecologically valid” models, studies of the neurocognitive organization of the brain may primarily benefit from the use of focal and anatomically restricted lesions. The present chapter focuses on such models. The primary focus of the chapter is a model in which the fimbria-fornix is selectively transected and hippocampal function consequently severely impaired. The method of this transection is described, and the neural and functional consequences of the lesion are reviewed. In order to best utilize such focal lesions in the analysis of neurocognitive organization additional methods are needed. These methods include combined and simultaneously inflicted focal lesions as well as the use of both organic and behavioral “challenge” techniques. Such an approach enables a deeper understanding of the mediating mechanisms at the level of anatomical structure and/or neurotransmitter system and prevents premature conclusions regarding the neurocognitive
AB - Animal models of traumatic brain injury are primarily utilized for the purpose of either (a) conducting basic research—for instance regarding the neurocognitive organization of the brain or (b) the development and evaluation of therapeutic interventions—such as pharmacological and behavioral methods as well as environmental manipulations. While studies focusing on development of therapeutic methods may primarily call for the use of more “ecologically valid” models, studies of the neurocognitive organization of the brain may primarily benefit from the use of focal and anatomically restricted lesions. The present chapter focuses on such models. The primary focus of the chapter is a model in which the fimbria-fornix is selectively transected and hippocampal function consequently severely impaired. The method of this transection is described, and the neural and functional consequences of the lesion are reviewed. In order to best utilize such focal lesions in the analysis of neurocognitive organization additional methods are needed. These methods include combined and simultaneously inflicted focal lesions as well as the use of both organic and behavioral “challenge” techniques. Such an approach enables a deeper understanding of the mediating mechanisms at the level of anatomical structure and/or neurotransmitter system and prevents premature conclusions regarding the neurocognitive
KW - Faculty of Social Sciences
KW - Focal lesions
KW - Fimbria-fornix
KW - Hippocampus
KW - Prefrontal cortex
KW - Combined lesions
KW - Neurocognitive organization
KW - Cognitive recovery
KW - Behavioral challenges
KW - Organic challenges
KW - Rat
U2 - 10.1007/978-1-4939-9711-4_2
DO - 10.1007/978-1-4939-9711-4_2
M3 - Book chapter
T3 - Neuromethods
SP - 19
EP - 46
BT - Animal Models of Neurotrauma
A2 - Risling, Mårten
A2 - Davidsson, Johan
PB - Springer
ER -
ID: 223569641