Is aberrant affective cognition an endophenotype for affective disorders? - A monozygotic twin study
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Is aberrant affective cognition an endophenotype for affective disorders? - A monozygotic twin study. / Meluken, Iselin; Ottesen, Ninja M; Harmer, C J; Scheike, Thomas; Kessing, Lars Vedel; Vinberg, Maj; Miskowiak, Kamilla Woznica.
In: Psychological Medicine, Vol. 49, No. 6, 2019, p. 987-996.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Is aberrant affective cognition an endophenotype for affective disorders? - A monozygotic twin study
AU - Meluken, Iselin
AU - Ottesen, Ninja M
AU - Harmer, C J
AU - Scheike, Thomas
AU - Kessing, Lars Vedel
AU - Vinberg, Maj
AU - Miskowiak, Kamilla Woznica
PY - 2019
Y1 - 2019
N2 - BACKGROUND: Identification of endophenotypes can improve prevention, detection and development of new treatments. We therefore investigated whether aberrant affective cognition constitutes an endophenotype for affective disorders by being present in monozygotic (MZ) twins with unipolar or bipolar disorder in partial remission (i.e. affected) and their unaffected co-twins (i.e. high-risk) relative to twins with no family history of affective disorder (i.e. low-risk).METHODS: We conducted an assessor blind cross-sectional study from 2014 to 2017 of MZ twins using Danish population-based registers in recruitment. Twins attended one test session involving neurocognitive testing, clinical ratings and questionnaires. Main outcomes were attention to and recognition of emotional facial expressions, the memory of emotional self-referential words, emotion regulation and coping strategies.RESULTS: Participants were 103 affected, 44 high-risk and 36 low-risk MZ twins. Groups were demographically well-balanced and showed comparable non-affective cognitive performance. We observed no aberrant affective cognition in affected and high-risk relative to low-risk twins. However, high-risk twins displayed attentional avoidance of emotional faces (ps ⩽ 0.009) and more use of task-oriented coping strategies (p = 0.01) compared with affected twins. In contrast did affected twins show more emotion-oriented coping than high- and low-risk twins (ps ⩽ 0.004).CONCLUSIONS: Our findings provide no support of aberrant affective cognition as an endophenotype for affective disorders. High-risk twins' attentional avoidance of emotional faces and greater use of task-oriented coping strategies may reflect compensatory mechanisms.
AB - BACKGROUND: Identification of endophenotypes can improve prevention, detection and development of new treatments. We therefore investigated whether aberrant affective cognition constitutes an endophenotype for affective disorders by being present in monozygotic (MZ) twins with unipolar or bipolar disorder in partial remission (i.e. affected) and their unaffected co-twins (i.e. high-risk) relative to twins with no family history of affective disorder (i.e. low-risk).METHODS: We conducted an assessor blind cross-sectional study from 2014 to 2017 of MZ twins using Danish population-based registers in recruitment. Twins attended one test session involving neurocognitive testing, clinical ratings and questionnaires. Main outcomes were attention to and recognition of emotional facial expressions, the memory of emotional self-referential words, emotion regulation and coping strategies.RESULTS: Participants were 103 affected, 44 high-risk and 36 low-risk MZ twins. Groups were demographically well-balanced and showed comparable non-affective cognitive performance. We observed no aberrant affective cognition in affected and high-risk relative to low-risk twins. However, high-risk twins displayed attentional avoidance of emotional faces (ps ⩽ 0.009) and more use of task-oriented coping strategies (p = 0.01) compared with affected twins. In contrast did affected twins show more emotion-oriented coping than high- and low-risk twins (ps ⩽ 0.004).CONCLUSIONS: Our findings provide no support of aberrant affective cognition as an endophenotype for affective disorders. High-risk twins' attentional avoidance of emotional faces and greater use of task-oriented coping strategies may reflect compensatory mechanisms.
KW - Faculty of Social Sciences
KW - Affective cognition
KW - affective disorder
KW - emotion processing
KW - emotion regulation
KW - endophenotype
KW - twin study
U2 - 10.1017/S0033291718001642
DO - 10.1017/S0033291718001642
M3 - Journal article
C2 - 29962367
VL - 49
SP - 987
EP - 996
JO - Psychological Medicine
JF - Psychological Medicine
SN - 0033-2917
IS - 6
ER -
ID: 203246852