A phenylpropanoid, a slovenolide, two sulphur-containing germacranes and Ca+2-ATPase inhibitors from Thapsia villosa
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
A phenylpropanoid 1, a slovenolide 2, and two germacranes bearing a methylthiopropenoate moiety, 3 and 4, along with twenty known metabolites have been isolated from the roots of THAPSIA VILLOSA var. VILLOSA L. The structures of two known phenylpropanoids 5 and 6 have been corrected. Compounds 7 and 8 showed activity as potential inhibitors of the sarco- and endoplasmic Ca (2+)-dependent ATPases (SERCA) pump. Compounds 9, 10 and 11 increased significantly the cytoplasmic free calcium concentration ([Ca (2+)] (c)) in human platelets in a concentration-dependent manner.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Planta Medica |
Vol/bind | 76 |
Udgave nummer | 3 |
Sider (fra-til) | 284-290 |
ISSN | 0032-0943 |
DOI | |
Status | Udgivet - 2010 |
Bibliografisk note
© Georg Thieme Verlag KG Stuttgart · New York.
- Det tidligere Farmaceutiske Fakultet
Forskningsområder
ID: 14119578