Low diversity of foot-and-mouth disease serotype C virus in Kenya: evidence for probable vaccine strain re-introductions in the field
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Low diversity of foot-and-mouth disease serotype C virus in Kenya : evidence for probable vaccine strain re-introductions in the field. / Sangula, A K; Siegismund, H R; Belsham, G J; Balinda, S N; Masembe, C; Muwanika, V B.
I: Epidemiology and Infection, Bind 139, Nr. 2, 2011, s. 189-196.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Low diversity of foot-and-mouth disease serotype C virus in Kenya
T2 - evidence for probable vaccine strain re-introductions in the field
AU - Sangula, A K
AU - Siegismund, H R
AU - Belsham, G J
AU - Balinda, S N
AU - Masembe, C
AU - Muwanika, V B
PY - 2011
Y1 - 2011
N2 - Most viruses are maintained by complex processes of evolution that enable them to survive but also complicate efforts to achieve their control. In this paper, we study patterns of evolution in foot-and-mouth disease (FMD) serotype C virus isolates from Kenya, one of the few places in the world where serotype C has been endemic and is suspected to remain. The nucleotide sequences encoding the capsid protein VP1 from eight isolates collected between 1967 and 2004 were analysed for patterns of sequence divergence and evolution. Very low nucleotide diversity (pi=0.0025) and remarkably little change (only five segregating sites and three amino-acid changes) were observed in these isolates collected over a period of almost 40 years. We interpret these results as being suggestive of re-introductions of the vaccine strain into the field. The implications of these results for the maintenance of serotype C FMD virus and the use of vaccination as a control measure in Kenya are discussed.
AB - Most viruses are maintained by complex processes of evolution that enable them to survive but also complicate efforts to achieve their control. In this paper, we study patterns of evolution in foot-and-mouth disease (FMD) serotype C virus isolates from Kenya, one of the few places in the world where serotype C has been endemic and is suspected to remain. The nucleotide sequences encoding the capsid protein VP1 from eight isolates collected between 1967 and 2004 were analysed for patterns of sequence divergence and evolution. Very low nucleotide diversity (pi=0.0025) and remarkably little change (only five segregating sites and three amino-acid changes) were observed in these isolates collected over a period of almost 40 years. We interpret these results as being suggestive of re-introductions of the vaccine strain into the field. The implications of these results for the maintenance of serotype C FMD virus and the use of vaccination as a control measure in Kenya are discussed.
KW - Faculty of Science
KW - FMDV serotype C
KW - Kenya
KW - sequence divergence
KW - vaccine strain
U2 - 10.1017/S0950268810000580
DO - 10.1017/S0950268810000580
M3 - Journal article
C2 - 20334728
VL - 139
SP - 189
EP - 196
JO - Epidemiology and Infection
JF - Epidemiology and Infection
SN - 0950-2688
IS - 2
ER -
ID: 21307749