Effects of estrogen replacement and lower androgen status on skeletal muscle collagen and myofibrillar protein synthesis in postmenopausal women
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Effects of estrogen replacement and lower androgen status on skeletal muscle collagen and myofibrillar protein synthesis in postmenopausal women. / Hansen, M; Skovgaard, D; Reitelseder, S; Holm, Lars; Langberg, H.; Kjær, Michael.
I: Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, Bind 67, Nr. 10, 2012, s. 1005-1013.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Effects of estrogen replacement and lower androgen status on skeletal muscle collagen and myofibrillar protein synthesis in postmenopausal women
AU - Hansen, M
AU - Skovgaard, D
AU - Reitelseder, S
AU - Holm, Lars
AU - Langberg, H.
AU - Kjær, Michael
PY - 2012
Y1 - 2012
N2 - Our aim was to determine synthesis rate of myofibrillar and collagen proteins in 20 postmenopausal women, who were either nonusers (Controls) or users of estrogen replacement therapy (ERT) after hysterectomy/oophorectomy. Myofibrillar and muscle collagen protein fractional synthesis rate (FSR) were determined in a nonexercised leg and 24 hours after exercise in the contralateral leg. A significant interaction between treatment and mechanical loading was observed in myofibrillar protein FSR. At rest, myofibrillar protein FSR was found to be lower in ERT users than in Controls. Exercise enhanced myofibrillar protein FSR only in ERT users. Similarly, muscle collagen FSR tended to be lower in ERT users compared with Controls. In ERT participants, the androgen profile was reduced, whereas estradiol and sex hormone–binding globulin were higher. In conclusion, at rest, myofibrillar protein FSR was lower in hysterectomized/oophorectomized women using ERT compared with healthy postmenopausal women. Nevertheless, resistance exercise in combination with ERT seems to have a counteracting effect on myofibrillar FSR in hysterectomized/oophorectomized women.
AB - Our aim was to determine synthesis rate of myofibrillar and collagen proteins in 20 postmenopausal women, who were either nonusers (Controls) or users of estrogen replacement therapy (ERT) after hysterectomy/oophorectomy. Myofibrillar and muscle collagen protein fractional synthesis rate (FSR) were determined in a nonexercised leg and 24 hours after exercise in the contralateral leg. A significant interaction between treatment and mechanical loading was observed in myofibrillar protein FSR. At rest, myofibrillar protein FSR was found to be lower in ERT users than in Controls. Exercise enhanced myofibrillar protein FSR only in ERT users. Similarly, muscle collagen FSR tended to be lower in ERT users compared with Controls. In ERT participants, the androgen profile was reduced, whereas estradiol and sex hormone–binding globulin were higher. In conclusion, at rest, myofibrillar protein FSR was lower in hysterectomized/oophorectomized women using ERT compared with healthy postmenopausal women. Nevertheless, resistance exercise in combination with ERT seems to have a counteracting effect on myofibrillar FSR in hysterectomized/oophorectomized women.
KW - Aged
KW - Androgens
KW - Case-Control Studies
KW - Collagen
KW - Cross-Sectional Studies
KW - Estradiol
KW - Estrogen Replacement Therapy
KW - Exercise
KW - Female
KW - Humans
KW - Hysterectomy
KW - Middle Aged
KW - Muscle Proteins
KW - Muscle, Skeletal
KW - Ovariectomy
KW - Postmenopause
KW - Sex Hormone-Binding Globulin
U2 - 10.1093/gerona/gls007
DO - 10.1093/gerona/gls007
M3 - Journal article
C2 - 22389460
VL - 67
SP - 1005
EP - 1013
JO - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences
JF - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences
SN - 1079-5006
IS - 10
ER -
ID: 44914172