Muscle after spinal cord injury
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Muscle after spinal cord injury. / Biering-Sørensen, Bo; Kristensen, Ida Bruun; Kjaer, Michael; Biering-Sørensen, Fin.
I: Muscle & Nerve, Bind 40, Nr. 4, 2009, s. 499-519.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Muscle after spinal cord injury
AU - Biering-Sørensen, Bo
AU - Kristensen, Ida Bruun
AU - Kjaer, Michael
AU - Biering-Sørensen, Fin
N1 - Keywords: Adenosine Triphosphatases; Animals; Cats; Disease Models, Animal; Female; Glycolysis; Humans; Male; Mice; Muscle Contraction; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Muscle, Skeletal; Oxidation-Reduction; Rabbits; Rats; Regional Blood Flow; Spinal Cord Injuries Times Cited: 0ReviewEnglishBiering-Sorensen, BCopenhagen Univ Hosp, Clin Spinal Cord Injuries, Ctr Neurosci, Rigshosp, Havnevej 25, DK-3100 Hornbaek, DenmarkCited References Count: 106506SAJOHN WILEY & SONS INC111 RIVER ST, HOBOKEN, NJ 07030 USAHOBOKEN
PY - 2009
Y1 - 2009
N2 - The morphological and contractile changes of muscles below the level of the lesion after spinal cord injury (SCI) are dramatic. In humans with SCI, a fiber-type transformation away from type I begins 4-7 months post-SCI and reaches a new steady state with predominantly fast glycolytic IIX fibers years after the injury. There is a progressive drop in the proportion of slow myosin heavy chain (MHC) isoform fibers and a rise in the proportion of fibers that coexpress both the fast and slow MHC isoforms. The oxidative enzymatic activity starts to decline after the first few months post-SCI. Muscles from individuals with chronic SCI show less resistance to fatigue, and the speed-related contractile properties change, becoming faster. These findings are also present in animals. Future studies should longitudinally examine changes in muscles from early SCI until steady state is reached in order to determine optimal training protocols for maintaining skeletal muscle after paralysis.
AB - The morphological and contractile changes of muscles below the level of the lesion after spinal cord injury (SCI) are dramatic. In humans with SCI, a fiber-type transformation away from type I begins 4-7 months post-SCI and reaches a new steady state with predominantly fast glycolytic IIX fibers years after the injury. There is a progressive drop in the proportion of slow myosin heavy chain (MHC) isoform fibers and a rise in the proportion of fibers that coexpress both the fast and slow MHC isoforms. The oxidative enzymatic activity starts to decline after the first few months post-SCI. Muscles from individuals with chronic SCI show less resistance to fatigue, and the speed-related contractile properties change, becoming faster. These findings are also present in animals. Future studies should longitudinally examine changes in muscles from early SCI until steady state is reached in order to determine optimal training protocols for maintaining skeletal muscle after paralysis.
U2 - 10.1002/mus.21391
DO - 10.1002/mus.21391
M3 - Journal article
C2 - 19705475
VL - 40
SP - 499
EP - 519
JO - Muscle & Nerve
JF - Muscle & Nerve
SN - 0148-639X
IS - 4
ER -
ID: 18764148