Physicochemical stimulus-responsive systems targeted with antibody derivatives
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Physicochemical stimulus-responsive systems targeted with antibody derivatives. / Mohammadi, Rezvan ; Ghani, Sepideh ; Arezumand , Roghaye; Farhadi, Shohreh ; Khazaee-Poul, Yalda ; Kazemi, Bahram ; Yarian, Fatemeh ; Noruzi, Somaye ; Alibakhshi , Abbas ; Jalili, Mahsa; Aghamiri, Shahin .
I: Current Molecular Medicine, Bind 24, Nr. 10, 2024, s. 1250-1268.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Physicochemical stimulus-responsive systems targeted with antibody derivatives
AU - Mohammadi, Rezvan
AU - Ghani, Sepideh
AU - Arezumand , Roghaye
AU - Farhadi, Shohreh
AU - Khazaee-Poul, Yalda
AU - Kazemi, Bahram
AU - Yarian, Fatemeh
AU - Noruzi, Somaye
AU - Alibakhshi , Abbas
AU - Jalili, Mahsa
AU - Aghamiri, Shahin
N1 - CURIS 2023 NEXS 184
PY - 2024
Y1 - 2024
N2 - The application of monoclonal antibodies and antibody fragments with the advent of recombinant antibody technology has made notable progress in clinical trials to provide a regulated drug release and extra targeting to the special conditions in the function site. Modification of antibodies has facilitated using mAbs and antibody fragments in numerous models of therapeutic and detection utilizations, such as stimuli-responsive systems. Antibodies and antibody derivatives conjugated with diverse stimuli-responsive materials have been constructed for drug delivery in response to a wide range of endogenous (electric, magnetic, light, radiation, ultrasound) and exogenous (temperature, pH, redox potential, enzymes) stimuli. In this report, we highlighted the recent progress on antibody-conjugated stimuli-responsive and dual/multi-responsive systems that affect modern medicine by improving a multitude of diagnostic and treatment strategies.
AB - The application of monoclonal antibodies and antibody fragments with the advent of recombinant antibody technology has made notable progress in clinical trials to provide a regulated drug release and extra targeting to the special conditions in the function site. Modification of antibodies has facilitated using mAbs and antibody fragments in numerous models of therapeutic and detection utilizations, such as stimuli-responsive systems. Antibodies and antibody derivatives conjugated with diverse stimuli-responsive materials have been constructed for drug delivery in response to a wide range of endogenous (electric, magnetic, light, radiation, ultrasound) and exogenous (temperature, pH, redox potential, enzymes) stimuli. In this report, we highlighted the recent progress on antibody-conjugated stimuli-responsive and dual/multi-responsive systems that affect modern medicine by improving a multitude of diagnostic and treatment strategies.
KW - Faculty of Science
KW - Stimulus-responsive systems
KW - Derivatives of antibody
KW - Targeted delivery of antibody
KW - Antibody
KW - Endogenous and exogenous stimuli
U2 - 10.2174/1566524023666230818093016
DO - 10.2174/1566524023666230818093016
M3 - Review
C2 - 37594115
VL - 24
SP - 1250
EP - 1268
JO - Current Molecular Medicine
JF - Current Molecular Medicine
SN - 1566-5240
IS - 10
ER -
ID: 362797689